Signiifcance Of24h Urine Metabolism Analysis For Uirnary Calculus

Objective To define the difference of blood chemistry results，24-h urine analysisresult，α1-microglodulin(α1-MG) and β2-microglodulin (β2-MG) between thosepatients suffering from urolithiasis and non-urolithiasis at the same time period.Methods Data from100patients admitted to the Department of Urology, First Aff-iliated Hospital of Anhui Medical University from July,2010to September,2010wereretrospectively reviients(22man,12women)were diagnosed as non-urolithiasis. Bloodand urine were tewed.66patients(45man,21women)suffered from urolithiasis, and34pataken from the patient the next morning after admission. blood biochemistry and uri-ne biochemical24h measured by automatic biochemistry analyzer.Measured by radio-immunoassay α1-MG and β2-MG content.Results Patients’ ages in urolithiasis group varied from13to78years and the male tofemale ratio was2.1:1.0. The patients in non-urolithiasis group aged from12to80yearsand the male to female ratio was1.8:1.0. There was difference in the levels of serumcreatinine and blood urea nitrogen between urolithiasis and non-urolithiasis groups(P<0.05).In contrast to subjects without stone,those with urolithiasis,more likely to havehigher level of urinary α1-MG and β2-MG, especially in calcium oxalate stone groupand urolithiasis oliguria group.But there were no differences in the urinary electrolytelevels. Polyuria urolithiasis urinary Ca, P levels higher than urolithiasis oliguria groupand control group.Group of non-calcium oxalate stones urinary uric acid levels higherthan calcium oxalate and control groups, the difference was statistically significant. Conclusions One24-hour urine sample is sufficient for metabolic evaluation ofrecurrent stone disease. In the formation of uric acid stones, uric acid increased asindependent risk factors. α1-MG, β2-MG may promote the formation of calcium oxalatestones.