Study Of The Mulberry Sanxian Gum Influence On The Clinical Efficacy Of Citp And The Expression Of Costimulatory Moleculr CD_8OmRNA

Objective:To observed the clinical effect of Mulberry Sanxian Gum (MSG)on CITP, evaluated the expressions of CD80mRNA in peripheral blood mononuclear cells from patients with CITP before and after treatment, and reveal the pathogenesis of CITP and effect mecheanism of chinese herbs on CITP.Methods:Give MSG to30CITP patients and observe the curative effect; RT-PCR method was used to measure the levels of CD80mRNA in peripheral blood mononuclear cells in patients with CITP and normal control subjects before and after MSG treatment.Results:The MSG has sure effect.The expressions of CD80mRNA in CITP group showed the same trends that the values were higher than normal controls and reduced after treatments. The levels of CD80mRNA in CITP group was significantly higher than that in normal control group (P<0.01). After MSG treatments, the expressions of CD80mRNA was reduced remarkably compared with that before treatments.Conclusion:Our study idicate curative effect of MSBEG on CITP is confirmed.There were overexpressions of costimulatory molecules CD80mRNA in peripheral blood mononuclear cells from patients with CITP. MSG may work through modifying the abnormal expression of costimulatory molecules, whereby regulating immune status so as to achieve remission or even cure CITP.