Clinical And Pathological Study Of Mammary Intraductal Papillary Neoplasm

Background:Mammary intraductal papillary neoplasms (IDPN) is a common disease of breast, including benign, borderline and malignant three parts. In breast tumor classification criteria of the WHO Pathology and Genetics of Tumors of the Breast and Female Genital Organs2003, mammary intraductal papillary neoplasms is classified as a group of diseases listed separately, and clearly classified as one of the carcinoma precancerous lesions. However, the diagnosis and treatment of such a disease should be paid more attention in clinical practice. However, in the clinical work, the identification of benign and malignant, the choice of surgical procedure is really difficult, there is still a large controversy in the domestic and foreign research, so the diagnosis and treatment of such diseases should be paid more attention.Objective:By analyzing the clinical manifestations and pathological features of the patients, to explore the clinical and pathological characteristics of mammary intraductal papillary neoplasms, and provide a reference for clinical diagnosis and treatment.Methods:A total of244patients (266sides) diagnosed with mammary intraductal papillary neoplasms (IDPN) is analyzed, which is acquired from the Qilu Hospital. It’s clinical manifestations and pathological features are reviewed. The expression of estrogen receptor (ER), progesterone receptor (PR), CerbB-2were detected with immunohistochemistry. SPSS was used for data analysis.Results:1.Age of onset of mammary intraductal papillary neoplasms more than40years of age is statistically significant (χ2=9.29, P<0.05).2.The risk of mammary intraductal papillary neoplasms of both side of breast is no significant difference(χ2=1.29, P>0.05).3.Patients with mammary intraductal papillary neoplasms with clinical manifestations of breast mass (χ2=54.34, P<0.05), nipple discharge (χ2=7.80, P<0.05)are tend to be malignant tendency, patients with bloody nipple discharge are tend to be malignant tendency(χ2=4.99, P<0.05).4.Patients with or without history of mammary intraductal papilloma surgery has no statistical difference tend to be malignant tendency(χ2=0.27, P>0.05).5.Patients with mammary intraductal papillary neoplasms with clinical manifestations of breast mass (χ2=7.44, P<0.05), nipple discharge (χ2=4.74, P<0.05)are with high Inaccurate of intraoperative frozen pathological diagnosis, patients with bloody nipple discharge are tend to be with high Inaccurate of intraoperative frozen pathological diagnosis (χ2=4.99, P<0.05).Conclusion:1. Clinical manifestation of mammary intraductal papillary neoplasms patients with nipple discharge is most common, clinical manifestation of mammary intraductal papillary carcinoma patients with breast mass is most common;2. The average age of onset of mammary intraductal papillary carcinoma is significantly higher than the mammary intraductal papilloma, patients older than40-year-old mammary intraductal papillary neoplasms are tend to be malignant tendency;3. Intraoperative frozen pathological diagnosis of mammary intraductal papillary neoplasms is very difficult, how to improve the diagnostic accuracy of intraoperative frozen pathological is worthy of further study; 4. Patients with clinical manifestations of breast mass has the lowest accuracy of frozen pathological diagnosis, which suggests that it is very difficult to identify patients with the clinical manifestations of breast mass.