Effects Of Rosuvastatin And Atorvastatin On Renal Function A Meta-Analysis

Background:Several clinical trials reported inconsistent findings for the effects of rosuvastatin and atorvastatin on renal function. We undertook this meta-analysis to investigate the effects of these two statins on glomerular filtration rate (GFR) and proteinuria respectively, and determine which is better.Methods and Results:We searched PubMed, CENTRAL, and Web of Knowledge for randomized controlled trials. Eligible studies reported GFR and/or proteinuria during treatment with rosuvastatin or atorvastatin compared with control (placebo, no statins, or usual care), or rosuvastatin compared with atorvastatin head-to-head. Trials enrolled dialysis participants and teenagers were excluded. We assessed statistical heterogeneity with I2statistic and pooled results with random-effects model. The standardized mean differences (SMD) and ratio of means (ROM) were measured respectively to analysis GFR and proteinuria. Sixteen trials with a total number of24278participants were identified. Compared with control, changes in the SMD of GFR were0.04(95%CI,0.01to0.07) and0.59(95%CI,0.12to1.06) for rosuvastatin and atorvastatin respectively. The ROMs of proteinuria were0.59(95%CI,0.46to0.74) in rosuvastatin versus control group and1.23(95%CI,1.05to1.43) in the head-to-head comparison.Conclusions:Both rosuvastatin and atorvastatin improve GFR, and atorvastatin seems to be more effective in reducing proteinuria. The validity and clinical significance require high-quality intensive studies with composite clinic endpoints of kidney and death.