Evaluation Risk Factors Of Renal Function And Proteinuria In Young Obese Adults

Objective: We investigated the associated risk factors of renal function including proteinuria in young obese adults.Methods: A total of 2340 subjects who were aged from 20 to 39 years and received health examination in The Frist Hospital of Fujian Medical Universty from November 2008 to August 2009 were enrolled in this study. The Information includes name, gender, age, height, weight, body mass index (BMI), systolic blood pressure, diastolic blood pressure, serum creatinine (SCr), blood urea nitrogen (BUN), fasting blood glucose, uric acid (UA), triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL) and low-density lipoprotein (LDL). The subjects were stratified into four age groups (20-24, 25-29, 30-34 and 35-39 years) or into four groups based on the number of risk factors (hypertension, hyperglycemia, dslipidemia and hyperuricema). To investigate the prevalence of obesity or proteinuria. The relationship between obesity and risk factors and the relationship between obestiy and estimated glomerular filtration rate (eGFR) or proteinuria were analyzed.Results: The prevalence of obesity was 33.3%, proteinuria 2.5% in man. The prevalence of obesity was 7.5%, proteinuria 1.7% in women. Blood pressure, serum fasting glucose, uric acid, LDL levels was significantly higher, while HDL levels was significantly lowers, in the obese group compared with the non-obese group in both male and female subjects. There were no significant differences in eGFR between obese and non-obese groups. The eGFR of males is related to the age,UA,BMI,fasting glucose,TC,TG,LDL,HDL.The eGFR of females is related to UA,the age,BMI,diastolic blood pressure,fasting glucose and LDL. BMI increased significantly as the number of risk factors increased in both male and female subjects. Multivariate analysis revealed that hypertension,hyperglycemia,dyslipidemia and hyperuricemia were independently associated with obesity. eGFR decreased significantly as the number of risk factors increased in both male and female subjects. Obesity and the other risk factors were independently associated with proteinuria.Conclusion: The prevalence of obesity was 33.3%, proteinuria 2.5% in man. The prevalence of obesity was 7.5%, proteinuria 1.7% in women in healthy subjects younger than 40 years of age.The risk factors (hypertension,hyperglycemia,dslipidemia and hyperuricema) were independently associated with obesity. These findings indicated that obesity causes proteinuria concomitantly with other factors (hypertension,hyperglycemia,dslipidemia and hyperuricema).