A Comparative Research On The C-Tbna And Real-Time Ebus-Tbna For The Diagnosis Of Mediastinum And Lung Disease

BackgroundThere has been significant interest in real-time endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) for diagnosing in mediastinal and pulmonary diseases. But it is still controversial whether real-time endobronchial ultrasound transbronchial needle aspiration is superior to conventional transbronchial needle aspiration (TBNA).ObjectiveThe aim of this study was to compare the diagnostical yield of conventional transbronchial needle aspiration(TBNA) and endobronchial ultrasound guided transbronchial needle aspiration(EBUS-TBNA) for mediastinal and hilar lymph nodes on chest CT were included by reviewing the peer-reviewed literatures.MethodA comprehensive search performed using MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials (CCTR) databases by the end of February2012. Studies were selected by two reviewers independently using a standardized data extraction form. Two reviewers serially abstracted data for each article. Randomized Controlled Trials (RCTs) for published statistical analysis in people with TBNA comparing with EBUS-TBNA were selected. Proportions of outcome measures across treatment groups were compared by Chi-Square Test and95%confidence interval.Results There were six studies included for quantitative data synthesis had pooled cohort of718patients. The yield of EBUS-TBNA was superior to conventional TBNA(x2=37.922, P<O.001). Compared with the conventional TBNA, the yield of EBUS-TBNA showed the significant difference.ConclusionWe suggested that real-time EBUS guidance significantly increase the yield of conventional TBNA on mediastinal and hilar lymphadenopathy, both in malignant and non-malignant. Available evidence also demonstrated safety safe nature of this procedure. We believed that EBUS-TBNA should be widely used in future.