Effect Of Plasma Parathyroid Hormone Level On Coronary Artery Calcification

Objective:Coronary artery calcification is regarded as one of the most important predictors for cardiovascular events and the prognosis of coronary heart disease,and it also play an important role in the cardiovascular risk stratification. At present various imaging examinations (such as MSCT, IVUS) are the main technology for the qualitative and quantitative inspection of CAC, however there are few hematology indexes available that can reflect the extent of CAC more safely and conveniently. As the mechanism of CAC is further understood, some hormones and proteins related to and vessel calcification caused people’s interests, such as PTH, growth hormones, stomach hunger element, OPG, osteopontin, tire globulin-A etc.Researches associated with PTH and CAC are mostly concentrated in patients with end-stage kidney disease, there are few similar researches reported at home and abroad about the patients without end-stage renal disease, and the test aims to investigate the effect of plasma parathyroid hormone level on coronary artery calcification in patients without the end-stage renal disease.Methods:41cases that were administered in Shandong provincial hospital affiliated to Shandong university for est tightness or chest pain were treated as the research objects. Spiral CT was used to detect their coronary artery and calculate the coronary artery calcification score(CACS).Patients were divided into two groups:coronary calcification group and control group according to the total CACS.The patients’age, gender, diabetes history and LDL-C level were recorded respectively, and the difference of plasma parathyroid hormone levels between two groups was studied.Results:The plasma parathyroid hormone levels in coronary calcification group(197.27±59.50pg/ml) were higher than that in control group (151.83±29.97pg/ml)(p<0.05). To elucidate the independent association between the level of PTH and CAC, the level of PTH and other risk factors were entered into a logistic regression analysis model, we found that the elevated plasma PTH was the risk factor for coronary artery calcification (RR=1.040;95%confidence interval,1.002-1.079, P<0.05)Conclusion:Elevation of plasma parathyroid hormone levels may be considered to be a predictor of coronary calcification.