The Relationship Of Serum Selenium Level And Recurrence Of Graves’ Disease And Mechanism Study

[Objective]To investigate the role of serum selenium in the recurrence of Graves’ disease.[Methods] From April2011to July2011in Qilu Hospital affiliated to Shandong University, Ninety cases of Graves’disease were collected. All patients were divided into three groups:the new diagnosed group (12men,18women, average age,40.1±11.0years); the remission group (13men,17women, average age,35.7±9.8years);and the recurrence group (10men,20women, average age,38.4±13.6years). All the patients were out-patients and consistent with Graves’disease diagnostic criteria:(1) clinical symptoms and signs of hyperthyroidism;(2) diffuse thyroid enlargement (palpation or ultrasoud-confirmed), a small number of cases can be no goiter;(3) lower serum TSH concentration, and thyroid hormone concentration increased. Patients were selected except for other thyroid diseases and autoimmune diseases, liver and kidney disease, cancer and seriously infectious diseases, not using immunosuppressive agents, immunomodulatory drugs and selenium preparations. Thirty normal persons (15men,15women, average age,37.7±10.2years) were served as the healthy controls. The serum selenium levels were determined by atomic fluorescence spectrometry, the serum TRAb levels were determined by ELISA, the serum GSH-PX levels were determined by colorimetric method, the serum MDA levels were determined by TBA method, and the levels of serum thyroid hormone, TPOAb and TGAb were determined by electrochemiluminescence method. [Results](1)The levels of selenium in the new diagnosed and recurrence group were significantly lower than that of the control group (P<0.01), but there was no significant difference between the remission group the control group (P>0.05); the selenium level of the recurrence group had no significant difference compared with the new diagnosed group(P>0.05), but was significantly lower than that of the remission group (P<0.01);(2) the correlation analysis showed that the serum selenium level was in positive correlation with the GSH-PX level, but was in no correlation with the levels of FT3、FT4、TGAb、TPOAb and MDA; the level of serum selenium in Graves’disease groups was in negative correlation with the TRAb level.[Conclusions] The lower level of serum selenium may be involved in the recurrence of Graves’disease by affecting the levels of GSH-PX and TRAb.