Retrospective Analysis Of Clinical Efficacy Of Nephron Sparing Surgery For Renal Cell Carcinoma In Early Stage

ObjectiveTo evaluate the postoperative complications and recurrence rate of nephron sparing surgery (NSS) for the treatment of renal cell carcinoma in early stage. MethodsWe retrospectively analysed162patients who were diagnosed as renal cell carcinoma in Shandong Provincial Hospital, from January2006to January2011. Among them,87patients underwent open nephron sparing surgery, including49males and38females, with a mean age of46.4years (range24to73years old).The average tumor diameter is2.57cm (range1.5cm-4.4cm). The other75patients Underwent open radical nephrectomy, including41males and34females, with a mean age of48.7years (range26to75years old). The average tumor diameter is2.83cm (range1.7cm to4.6cm). The pathological stages of all patients were T1N0M0. We compared the incidence of postoperative complications and ratio of long-term recurrence metastasis in the two groups. Meanwhile, we compared the average operative time, blood loss, extubation drainage time and hospitalization duration after surgery. All statistical analysis were carried out in SPSS17.0statistical package.P<0.05means statistically significant difference. ResultsThe surgeries for162patients were successful. In the open open nephron sparing surgery group, the postoperative complications included postoperative hemorrhage in1cases (cured after Conservative treatment) and wound infection in1cases. With an average follow-up of 21.8months, there were local recurrence in1cases and no metastasis. In the open radical nephrectomy group, the postoperative complications included wound infection in2cases. With an average follow-up of22.3months, there were no local recurrence and metastasis. There were no other postoperative complications such as postoperative bleeding, urinary fistula, perinephric effusion associated with infection, the skin incision infections delay healing observed.There was no significant difference in the average operative time, blood loss, extubation drainage time and hospitalization duration after surgery between open nephron sparing surgery group and open radical nephrectomy group. ConclusionsNephron sparing surgery is a safe and effective treatment for renal ceil carcinoma in early stage.