Meta Analysis On Hereditary Effects Of Aristolochinc Acid、Lentinan、Lycium Barbarum And Glycyrrhetinic

Objective In order to evaluate the resistance capability to cyclophosphamide-induced geneticdamage of Lentinan、Lycium Barbarum、Glycyrrhetinic, and provide Chinese medicine repellantto the tissue damage in clinical cancer treatment. To evaluate the CⅡ gene mutations and DNAadducts in the Liver and Kidney cells caused by aristolochinc acids, and probe its hereditarytoxicity.Methods Retrieval Science Direct, Embase, Springer, Cochrane center, CNKI, VIP and PubMeddatabase etc, then collect the random or half random controlled trials about genetic damagecaused by aristolochinc acid, and valuate the literature with systematic review.7RCTs wereselected. Do subgroup analysis according to the monitoring site and measuring indicators.Articles about Lentinan、Lycium Barbarum and Glycyrrhetinic were searched from the database,using Cochrane systematic evaluation method.and ultimately18were selected. To assess thequality of the literature with the Jadad scoring method, and do subgroup analysis with Revman5.0software.Results Aristolochinc acid induced liver and kidney cells CⅡ gene mutations and promotedDNA adducts reaction. and it is more sensitive to the kidney cells (P <0.05). The MeanDifference and MeanDifference95%CI of Lentinan, Lycium Barbarum、Glycyrrhetinic werestatistically significant difference respectively（P <0.05）.Conclusion Lentinan, Lycium Barbarum、Glycyrrhetinic can inhibit micronucleus formationwith different intensity. Maybe the three substances can be used in the process of cancertreatment in combination with cyclophosphamide and other chemotherapeuticagents.Aristolochinc acid shows a certain genetic toxicity, and it has obvious effect in kidneydamage than in liver function.