Research Concentration Of N-terminal Fragment Of Pro．brain Natriuretic Peptide And Prognosis In Patients With Acute Cerebral Hemorrhage

Background Cerebral hemorrhage has higher incidence in ourcountry.The main cause of death with acute phase cerebral hemorrhage isintracranial hypertension,cerebral hernia, and pulmonary infection.Andmost of the patients could not recovery completely, and easily has thecomplications such as limb paralysis and vascular dementia. The recentstudies found that the N-terminal fragment of Pro． Brain NatriureticPeptide (NT-proBNP) may be involved in the pathological reaction to brainedema, inflammatory reaction and cell apoptosis in the cerebralhemorrhage,which can cause damage to brain tissue secondary, and may beone of the symbols of poor prognosis. That the NT-proBNP with the dynamicchange in the cerebral hemorrhage, the role in the identification ofcardioembolic stroke, the correlation with the severity of disease and itsaction mechanism has become a hotspot of the present research. Thisresearch focuses on the relationship of cerebral hemorrhage andNT-proBNP, the factors affecting the concentration of NT-proBNP，and itsclinical application and value in the cerebral hemorrhage. 0bjective1. To investigate the dynamic changes of plasma concentration ofNT-proBNP in the acute cerebral hemorrhage.2. To investigate the related factors affecting the concentration ofNT-proBNP, such as the volume of hemorrhage, neurological deficits, andthe hypertension.3. To investigate that the relation of plasma concentration ofNT-proBNP and prognosis in patients with acute cerebral hemorrhage.Methods A prospective control study was used. There were42patients in the cerebral hemorrhage group, who were in hospital within24hafter onset, and28cases in the healthy control group. The plasma level ofNT-proBNP on admission and the seventh day, general conditions, bleedingsite,volume of hemorrhage, Glasgow Coma Score(GCS), National Instituteof Health stroke scale(NIHSS), and prognosis of follow-up for six monthwere observed.Results1. The plasma level of NT-proBNP in the cerebral hemorrhage groupwas higher than in control (P<0.05) and was lower at the seventh day than onadmission (P<0.05).2. It was higher in patients with large hemorrhage or GCS≤8than inpatients with medium and small hemorrhage(P<0.05) or GCS>8(P<0.05).3. The higher the plasma level of NT-proBNP in patients with cerebral hemorrhage was, the poorer the recovery of neurologicimpairment for follow-up six months.Conclusion1. The plasma level of NT-proBNP was increased at acute phase aftercerebral hemorrhage and will slowly decrease after that.2. The bigger the volume of cerebral hemorrhage，the higher theplasma level of NT-proBNP, and the worse the prognosis.3. The plasma level of NT-proBNP could be one of important andshortcut indicators for monitoring the changes of condition and predictingprognosis in patients with cerebral hemorrhage.