Inlfuence Of Subclinical Hypothyroidism On The Pulse Wave Velocity C-reactive Protein And Platelet Activation In Patients With Coronary Heart Disease

Objective:(1)To observe the influence of subclinical hypothyroidism onbrachial-ankle pulse wave velocity （baPWV）, high sensitive c-reactive protein（hs-CRP）and platelet activator (CD62P、CD41) in patients with coronary heartdisease （CHD）.(2) To elucidate whether subclinical hypothyroidism is acardiovascular risk factor.(3) To provide a theoretical foundation on which the earlyrisk stratification, prognostic judgement and interventional therapy can be based forCHD patients complicated with subclinical hypothyroidism.Methods:56consecutive coronary heart disease patients were enrolled in ourhospital, and divided into two groups (of them28complicated with subclinicalhypothyroidism,28with euthyroidism). The level of fast serum total cholesterol(TC)、triglyceride(TG)、 HDL-ch、LDL-ch、homocystine、T3、T4、FT3、FT4、TSH、hs-CRP、 CD41and CD62P was measured in all patients, and their baPWVdetected. All value between the two groups was compared, and the association ofTSH with other value was evaluated through spss13.0software.Results:(1) The levels of TSH、TC、TG、LDL-ch、 hs-CRP、CD41、CD62Pand baPWV increased while HDL-ch decreased significantly in the CHD patientscomplicated with subclinical hypothyroidism as compared with those witheuthyroidism (P<0.05or P<0.01). Homocystine also increased in the CHD patientscomplicated with subclinical hypothyroidism as compared with those witheuthyroidism, but was not significant (P>0.05).(2) TSH correlated positively withTC、TG、LDL-ch、 hs-CRP、CD41、CD62P and baPWV (P<0.05or P<0.01),but negatively with HDL-ch(P<0.05).Conclusion: The result of our study indicates：(1) Subclinicalhypothyroidism can not only affect lipid and homocystine metabolism, but also isassociated with some cardiovascular risk factors such baPWV, hs-CRP and plateletactivator (CD62P、CD41),(2) Subclinical hypothyroidism may contribute a raisedcardiovascular risk to patients with coronary heart disease.(3)The detection of baPWV, hs-CRP and Platelet activator (CD62P、CD41) may has some enlightenmentfor the early risk stratification, prognostic judgement and interventional therapy inCHD patients complicated with subclinical hypothyroidism.