Evaluation Of The Effect And Security On Fentanil-propofol In Bronchoifbroscopy

Objection:1． The Research of Effect and Security about fentanyl combined withpropofolum in Conscius Sedation Bronchofibroscopy2．To observe two different methods of nasal congestion and oxygen mask andcompare the effect of preventing the hypoxemia during painless endoscopic bronch-oscopy.3．The Research of Effect and Security and the best dose of fentanyl combinedwith propofolum in Conscius Sedation Bronchofibroscopy about drunkard patientsMethods:1．180patients that prepared fiberoptic bronchoscopy were randomly dividedinto three groups, every group60cases. A group used continuous nasal oxygen(2L/min), B group used endoscopic oxygen mask． A and B groups were givenintravenous fentanyl combined with propofol anesthesia to conduct painlessbronchoscopy and C group was a routine bronchofibroscopy group, and the pulseoxygen saturation (Sp02), blood pressure (BP), heart rate (HR), ECG andintraoperative and postoperative discomfort response were observed in threegroups． Questionnaires for patients were performed after bronchoscopy．2．75drunkard patients were divided into three groups(25cases each group)： Igroup (fentanyl1.0μg/kg combined with propofolum)， II group (fentanyl1.25μg/kg combined with propofolum) and Ⅲ group (fentanyl1.5μg/kg combinedwith propofolum)， and choose another25patients of no drinking (ⅣGroup)(fentanyl1.0μg/kg combined with propofolum)， Unwell of patients such as coughand vomiting， HR， Sp02， SBP and DBP were observed．Results:1．There were lower rate of unwell in A and B groups than in C group． More than98.3％patients had no complaints and would like to receive repeated examination（P<0.01）． 2．First, The incidences of intraoperative hypoxemia in A group(53.3％) wassignificantly higher than B group(6.7%)． The intraoperative Sp02was significantlylower than preoperative in A group (P<0.05)． There were no statisticallysignificant of Sp02in comparing intraoperative with preoperative in B and Cgroups． The intraoperative SBP， DBP were lower than preoperative in A group(P<0.05)． There was no statistically significant of BP in comparing intraoperativewith preoperative in group B． The intraoperative SBP， DBP were higher thanpreoperative in C group (P<0.05)． There was no statistically significant of Sp02，SBP， DBP， HR in comparing postoperative with preoperative in three groups (allP>0.05)．There was no statistically significant of ECG in comparing postoperativewith preoperative in three groups (P>0.05)． The intraoperative ECG was higherthan preoperative in C group (P<0.05)．3．There were higher rate of unwell such as cough in Ⅰ group than in Ⅱ，Ⅲ，Ⅳ groups (P<0.05)． The Sp02in III group was significantly lower than in I groupand II group and Ⅳ group (P<0.05)．The intraoperative SBP，DBP，Sp02weresignificantly lower than preoperative in Ⅲ group (P<0.05)． There were nostatistically significant of intraoperative SBP， DBP， HR， Sp02in four groups(P>0.05)． There was no statistically significant of HR, SBP， DBP， Sp02incomparing postoperative with preoperative in four groups (P>0.05)． There was nostatistically significant about the incidence of adverse reactions such as nausea andvomiting of postoperative in four groups(P>0.05)．Conclusion:1．Painless bronchoscopy is safe, no pain, fewer adverse reactions byfentanyl combined with propofol intravenous anesthesia．2．The incidence of hypoxemia in nasal oxygen is higher than oxygen masks forfiberoptic bronchoscopy， and oxygen masks endoscopic method can effectivelyreduce the incidence of hypoxemia．3．Painless bronchoscopy is safe, no pain, fewer adverse reactions byfentanyl combined with propofol intravenous anesthesia． When fentanyl withpropofol for conscious sedation bronchofibroscopy， the proper dosage of fentanylwas1.25μg/kg.．...