Study On The Hypoglycemic Action Of The Mulberry Leaves In Diabetic Rats

By alloxan-induced hyperglycemic rats for feeding mulberry leaves-tests and analysis on the5indicators from fasting glucose (FG),2-hour postprandial blood glucose (2-PBG), oral glucose tolerance test(OGTT), blood lipids(BL), body weight(BW)by experiment. It shows the treatment effects of diabetic rats.Data analysis found that mulberry leaves in diabetic rats5indicators with varying degrees of treatment, the performance is as follows:1, The alloxan-induced rat’s Fasting glucose (FG) increased significantly after3days and5weeks, which showed an significant difference between the model group and the saline group (P<0.01). After being fed with mulberry leaves, the FG of each dose group has lowered with an varying degrees, on which, middle-dose group started from the second week and high-dose group started from the second and forth week to have an significant difference with the model group (P<0.01). This data shows mulberry leaves have the function of decreasing the alloxan-induced rat’s FG.2, The alloxan-induced rat’s postprandial blood glucose (PBG) increased significantly, which showed an significant difference between the model group and the saline group (P <0.01). After being fed with mulberry leaves, the PBG of each dose group has lowered with an varying degrees, on which, middle-dose group and high-dose group started from the second week to have an significant difference with the model group (P<0.05or P<0.01). This data shows mulberry leaves have the function of decreasing the alloxan-induced rat’s PBG.3, The experimental results of the alloxan-induced rat’s oral glucose tolerance test (OGTT) show that the Blood glucose levels (BGL) of each dose group was lower than the saline+maltose group in difference time. High-dose group and middle dose group’s BGL were lower than the saline+maltose group, which showed a significant difference with the saline+maltose group (P<0.01or P<0.05). This data shows mulberry leaves have the function of decreasing and delaying the peak blood glucose of the alloxan-induced rats in0.5hours.4, Alloxan-induced rat’s Triglycerides (TRI) and Total cholesterol (CHOL) increased significantly, which showed a significant difference between the model group and the saline group (P<0.01or P<0.05). After being fed with mulberry leaves, the TRI and CHOL level of each dose group showed an trend of decreas, which displayed no significant difference with the model group (P>0.05). This data shows mulberry leaves haven’t the function of decreasing the alloxan-induced rat’s blood lipids (BL) level.5, The alloxan-induced rat’s body weight (BW) increased significantly, which showed an obvious difference between the model group and the saline group (P<0.01). After being fed with mulberry leaves, the weight of each dose group all displayed an inhibitory effect on the decreas of their BW, on which, high-dose group started from the second week and middle-dose group started from the forth week to have an significant difference with the model group (P<0.01or P<0.05). This data shows mulberry leaves have the function of inhibiting decrease of the alloxan-induced rat’s BW.