Investigation On The Life Quality For HBV-related Liver Cirrhosis Patients And The Impact Of UC-MSC Treatment

OBJECTIVES:To evaluate quality of life of HBV-related liver cirrhosis (LC) patients and studythe impact of it before and after the treatment with UC-MSC，to analysis the affectedfactors.METHODS:In the first part，250HBV-related LC patients were investigated using a self-madequestionnaire and the MOS SF-36item short form health survey （SF-36）that includephysical functioning（PF），role-physical（RP）， bodily pain（BP），vitality（VT），social functioning（SF），general health（GH），role-emotional（RE）and mental health（MH）.In the second part，208HBV-related LC patients were divided into control group(n=100) with routine treatment and treatment group (n=108) with UC-MSC treatmenton the basis of routine treatment for3months. The patients completed the MOS SF-36item short form health survey（SF-36）respectively before treatment and after12weeksand1year of being treatment By a method base on factors analysis，the eight scales canbe summarized into physical component summary（PCS）and mental componentsummary（MCS）.Factors analysis were applied to determine the effect of a lotsexplanatory variables such as age，gender，educational level，marital status，payment，liver function grade and so forth，on quality of life. RESULTS:1. The life quality were significantly reduced of LC patients compared with the normalmodel（p<0.01）.2. All of the scales were decrease in LC patients， especially in GH、VT、RE、SF、MH；No significant difference between male and female（p>0.05）.3. Multiple linear stepwise regression analysis found that age，marital status，payment，hospitalization time，liver function grade，ascites and HBVDNA were significant factorsof life quality of LC patients.4. After being treatment，the score of SF-36increased in both groups，but the treatmentgroup was superior to the control group，and it still last a high level after1year of beingtreatment.5. Multiple factors analysis showed that age，marital status，hospitalization time，liverfunction grade，ascites and HBVDNA were the most significant factors of LC patientswith UC-MSC treatment.CONCLUSIONS:HBV-related LC patients have the poor quality of life。It is an effective method toestablish good doctor-patient relationship，increased self-confidence，strengthen familyand social support and supply individual and high quality serviceUC-MSC treatment can effectively alleviate the clinical symptoms and incompliance with clinical actual performance. It is suggested that the evaluation ofquality of life may be an effective means to assess the curative effect.