Research On Pharmacodynamics And Toxicity Of Aconite Dry Ginger Of Compatibility

Purpose: Use toxic Chinese medicine aconite as the breakthrough point, choosecompatibility of aconite dried ginger as the research object, investigating the effect of efficacyand toxicity about compatibility of aconite dried ginger before and after.Methods:①Use pentobarbital sodium femoral venous injection method, establish ratacute heart failure animal model, record hemodynamic parameters by MP-150physiologicaldata recorder, observe the changes of hemodynamic parameters of compatibility before andafter.②Through ELISA kit detect the content of rat plasma NT-proBNP、ANP、PRA、AngⅡ、ALD, observe the regulation function of compatibility of aconite dried ginger beforeand after to humoral factor.③Through detect the dose LD50values in mice to evaluate andcompare the basic toxicity of compatibility of aconite dried ginger before and after.Results:①As the index to heart function, the hemodynamic investigation results ofacute heart failure rat show that all groups can improve the hemodynamic parameters of acuteheart failure in rat compatibility before and after. The cardiac contractile function relative ease,after compatibility of dried ginger, with the amount of dried ginger increased, the effectenhanced.②After compatibility of aconite dried ginger, the level of rat plasma NT-proBNP、ANP、PRA、AngⅡ、ALD down, which show that the regulation function to some humoralfactor after compatibility of aconite dried ginger.③Acute toxicity test results show that theLD50of FZ, FG1:0.5, FG1:1, FG1:2is17.55g/kg crude drug,23.46g/kg crude drug,28.78g/kg crude drug and32.23g/kg crude drug. It is clearly that after compatibility the LD50increased significantly, which indicate that the toxicity greatly reduced after compatibility.Conclusions:①After compatibility of FG, the curative effect to acute heart failureenhanced, the mechanism maybe related to enhance force of cardiac muscle systole、improvecardiac energy metabolism、lower left ventricular end-diastolic pressure、improving the heartcompliance and regulate humoral factor, and then achieve the restoring yang and rescuingpatient from collapse purpose.②Dried ginger can reduce the toxicity of aconite and improvethe safety of medication.