TCM Syndrome Type2Diabetes And Hemodynamics And Microvascular Complications In Clinical Research Related

Objective:Type2diabetes mellitus (T2DM) the intrinsic link among the syndrome diff erenti-ation typing and blood rheology and microvascular complications,provide referenc e for T2DM clinical differential diagnosis,provide theoretical basis and clinical demonstr ation for integrative treatment of diabetes and preventand delay the microvascular compl ications.Methods:Selected from March2011to December2011,the Jiangsu Provincial Hospital of Endocrinology,confirmed a total of90cases of hospitalized patients with T2DM. Elig ible patients are in line with the1999WHO,IDF diagnostic criteria of type2diabetes, microvascular complications in those who meet the diagnostic criteria.Chinese medicine syndrome differentiation with reference to the2002Ministry of Health,Traditional Chine se Drug Guidelines for clinical research,Combined with clinical observation are divided i nto Yin and Heat Syndrome,Qi and Yin Deficiency,Yin and yang deficiency and blood stasis context card.Select both the hospital medical center20cases of healthy persons a s control group.Groups were observed in whole blood viscosity (high shear and low she ar),plasma viscosity,erythrocyte sedimentation rate,hematocrit, erythrocyte aggregation,fibri nogen,blood rheology index,and blood sugar,for statistical analysis and processing.Results:1.T2DM group compared with normal control group,the hemorheological indexe s increased significantly(P＜0.01);in TCM Syndrome,stasis context group were higher than other groups,including whole blood is low cut,high shear blood,plasma viscosity,erythroc yte aggregation,fibrinogen with the Yin and Heat Syndrome,Qi and yin deficiency,Yinan d yang deficiency,blood stasis context cards in ascending order,between the two groups, in addition to differences in plasma viscosity of yin and yang deficiency with blood sta sis context card is meaningless (P＞0.05),difference were statistically significant(P＜0.05,P＜0.01).2.The T2DM microvascular complications and without microvascular complications of blood rheology were higher than the normal control group (P＜0.05,.P＜0.01),microvas cular complications than those without microvascular complications group elevated,in whi ch whole blood high cutand low cut,plasma viscosity,erythrocyte sedimentation rate,fibrin ogen had statistically significant(P＜0.01),hematocrit,erythrocyte aggregation index had statistically significant (P＜0.05);difference between diabetic nephropathy,diabetic retinopat hy,and diabetic peripheral neuropathy were no significant(P＞0.05).3.T2DM patients with microvascular complications compared with without microvascular complications,FBG sig nificantly increased,the disease duration increased(P＜0.01).Along the direction of the yin and Heat Syndrome,Qi and yin Deficiency,yin and yang deficiency,blood stasis context permit,FBG increased,disease durationgradually extended,the difference of Qi and Yin de ficiency group and the yin and yang group,Yin and yang group and stasis context grou p,were no significant(P>0.05),the remaining differences between groups were statistically significant (P<0.05,P<0.01).T2DM patients with microvascular complications compared w ith without microvascular complications,Fins significantly lower (P<0.01),Along the direct ion of the Yin and heat syndrome,Qi and yin deficiency,Yin and yang deficiency,blood stasis context permit,Fins level declined,the difference of Yin and yang group and stasis context group was no significant(P>0.05),the remaining differences between groups were statistically significant (P<0.05, P<0.01).4.Along the direction of the Yin and heat syndr ome,Qi and yin deficiency,Yin and yang deficiency,blood stasis context permit,the incide nee of T2DM microvascular complications gradually increased,Yin and Heat Syndrome a nd the remaining three groups were significantly different.Conclusion:1.T2DM patients compared with normal control group hemorheological abnor mality increased,patients with microvascular complications than those without microvascu lar complications hemorheology in patients with significantly elevated,hemorheology inde xes can be used as risk factors and clinical predictors of reference for T2DM,especially microvascular complications.2.Along the direction of the yin and Heat Syndrome,Qi and yin Deficiency,yin and yang deficiency,blood stasis context permit,FBG elevated,Fins dec lined,course of disease extended,patients with T2DM condition gradually worsened.3.The T2DM TCM syndrome there are varying degrees of abnormal blood rheology,hemorheol ogical indexes can be used as T2DM syndrome type reference;stasis exists in the whole course of the patients with T2DM,with the direction of the Heat Syndrome with Yin,Qi and yin Deficiency,Yin and yang deficiency,blood stasis context card stasis extent and t he incidence of microvascular complications,gradually increased.Bleeding resistance is an important pathogenesis of microvascular complications.The clinical use of blood circulati on is important for treatment of T2DM and microvascular complicationsand delaying dis ease progression.4.T2DM patients with microvascular complications compared with witho ut microvascular complications,FBG increased,Fins declined and course of disease extend ed.Along the DPN,DN,DR direction,FBG increased,Fins declined and course of disease e xtended,but no significant difference.