The Distribution Of The Syndrome Elements Of TCM In The Elderly Patients With Hypertension During The Development Of Carotid Atherosclerosis And It’s Inflammatory Mechanism

objective:1.To observe the distribution of syndrome elements of TCM in the elderly patients with hypertension,Using the method of four diagnostic information.2.To analysis of the distribution syndrome element of TCM of elderly hypertensive patients with carotid atherosclerosis development.3.To analysis of the relationship of high sensitivity C-reactive protein(CRP)and dinterleukin6(IL-6)in elderly hypertensive patients with different level of carotid atherosclerosis.Methods:1.Based on the diagnostic crite—a of elderly patients with hypertension,the election into170cases of elderly hypertensive patients,by the different of carotid intimamedia thickness(IMT),170patients were divided into three group:normal group of45cases,thickening group of63cases,plaque group of62cases.2.All data were applied for statistical analysis by SPSS13.0paekage.Measurement data were presented as mean±standard deviation;measurable indicators between the two groups compared with two-tailed,student-t test；multiple measurable indic-ators were few compared Whell homogeneity of variance single factor analysis of variance,variance missing,the use of multiple independent sample non-parametric K-S rank test.(P<0.05considered statistically signincant difference).RCSUIts:1.The distribution of syndrome elelments of TCM in elder hypertensive palients:the total frequency of syndrome elements0f TCM in170cases clderly hypertensivc pat-ients are206,in which phlegm60cases,accounting for29%;qi deficiency42cases, accounting for20%;yin deficiency42cases,accounting for20%; yang hyperactivity38cases,18%; blood deficiency of18cases,accounting for7percent;blood stasis5c-ases,2%; yang deficiency1cases,accounting for0.4%.the syndrome element of TCM appear to frequency as follows:phlegm,yin deficiency, qi deficiency, yang hyperactivi-ty, blood deficiency, blood stasis,yang deficiency.demonstration syndrome element and the asthenia syndrome element accounting for50%,phlegm often appear alon-e.multicard elements of TCM characteristics:qi deficiency and mixed blood deficie-ncy (17cases, accounting10%),Qi and Yin deficiency (11cases,accounting for6%),Yin deficiency and yang hyperactivity(7cases,accounting4%).2. The distribution of syndrome elements of TCM in elder hypertensive patients with different level of carotid atherosclerosis:in the normal group,the percentage of frequency of syndrome elements of TCM are as follows:Yin deficiency18cases (35%),Yang hyperactivity13cases (25%),Qi deficiency10cases (20%),phlegm6cases (12%),blood deficiency3cases (6%),blood stasis1case (2%).In the thickening group,the percentage of frequency of syndrome elements of TCM are as follows:Yin deficiency19cases (23%) Yang hyperactivity18cases (23%),phlegm18cases (23%),Qi deficiency18cases (23%),blood stasis3cases (4%),blood deficiency,2cases (4%).In the piaque group,the percentage of frequency of syndrome elements of TCM are as follows:phlegm36cases (49%),qi deficiency14cases (19%),blood deficiency12cases (13%),Yang hyperactivity7cases (9%),Yin deficiency6cases (5%),Yang deficiency1cease (1%),blood stasis1case (1%).The distribution of syndrome elements of TCM has a significant difference among the three groups (P <0.05).3. The average age of the plaque group is greater than the thickening group and normal group,and has statistically significant (P<0.05).The duration of hypertension of plaque group is significantly longer than the thickening group and normal group,and has statistically significant (P<0.05).4. With the levels of development of carotid atherosclerosis,the expression level IL-6and CRP is gradually increased.IL-6levels of plaque group is higher than the other two groups and has significant difference (P<0.01);expression of CRP levels of plaque group is higher than thickening group and have significant difference (P <0.05).5. In single element group, expression levels of IL-6high to low are:phlegm> Yang hyperactivity> Yin deficiency> Qi deficiency;expression levels of CRP in the order of:phlegm>Yin deficiency>qi deficiency>yang hyperactivity.The levels of Ⅱ-6in phlegm group is higher than other syndrome element group and has statistical significance (P<0.05);The levels of CRP in phlegm group is higher than the yang hyperactivity group,and has statistical significance (P<0.05).Single syndrome elements of TCM in the normal group,the average of IL-6and CRP as follows:phlegm>Yang hyperactivity>Yin deficiency>Qi deficiency,phlegm group has statistically significant compared with the other element group of TCM (P <0.01),the expression of CRP has no significant (P>0.05),in thickening group and plaque group there are no significant in expression levels of IL-6,CRP of single syndrome element of TCM.(P>0.05).6. In the folder syndrome elements groups,expression levels of IL-6from highest to lowest as follows:QI and blood deficiency>Qi andYin deficiency>Yin deficiency and Yang hyperactivity,expression levels of CRP from highest to lowest as follows:Yin deficiency and Yang hyperactivity>Qi andYin deficiency>Qi and blood deficiency,but there has no significant difference between expression levels of IL-6and CRP(P>0.05).6. Between single element group,the expression levels of CRP,IL-6in phlegm group is higher than non-phlegm syndrome element and has statistical difference (P <0.05),the expression levels of IL-6in solid syndrome element and imaginary element,Qi deficiency and non-qi deficiency have statistical difference(P<0.05). Conclusion:1. Syndrome elements of TCM in elderly hypertensive patients distribution has itsown unique characteristics,The overall solid syndrome element and imaginary element most seen,mainly single syndrome element is most common,part-folder syndrome element is more common in imaginary element.2. Syndrome elements of TCM with significant differences in distribution with carotid artery development process,mainly the gradual increase in phlegm element.it cloud may play an important part in carotid artery development process,phlegm can be used as a a predictor in elderly hypertensive patients with carotid atherosclerosis.3. The expression levels of CRP,IL-6in phlegm group is higher than non-phlegm syndrome element and has statistical difference (P<0.05),the phlegm syndrome element can be used as a reference index of the strength of inflammatory response in elderly patients with hypertension.4. increase with age,the extent of carotid atherosclerosis (the characteristics of atherosclerotic plaque formation) gradually increased;blood pressure has played a key role in the development of carotid atherosclerosis.5. With the development of carotid atherosclerosis,IL-6,CRP,an upward trend. suggesting that inflammation plays an important role in the development of carotid atherosclerosis.