Clinical Observation On The Bengdawan Compound In Treatment Of Chronic Renal Failure

BackgroundChronic renal failure (chronic renal failure, CRF) is a disease that occurs in a variety of foundation based on chronic kidney disease, the renal failures slowly and irreversibly onset of impaired renal function because of the severely impaired renal unit. Chronic renal failure(CRF) brings a huge threat to human health, and the state of the illness is complex and serious. Although the kidney transplant operation and blood purification technology development significantly increase the survival rate of patients, its associated cost is very expensive, and is a huge economic burden bringed to the patients. Besides, CRF remains with "Edema","Retention of Urine""Block and Repulsion disease","Urinary Toxin" and "kidney wind" of traditional chinese medicine (TCM). Decay of Spleen and Kidney, and wet and muddy blocks are considered the main pathogenesis of entirety of the disease. Modern research shows that, the TCM-enema for the therapy of CRF can achieve a certain effect, so it is one of the therapies of TCM on the current status of CRF.ObjectiveObservation of Bengdawan Compound enema in the treatment of chronic renal failure (CRF) and the clinical curative effect and its mechanism of action.MethodsMethods:83cases of CRF outpatients and inpatients, were randomly divided into treatment group44cases and control group46cases. The control group adopted conventional symptomatic treatment; group therapy in addition to conventional symptomatic treatment, combined with Bengdawan Compound enema treatment. Observation of project:include (1) the two groups before and after treatment of TCM syndrome integral;(2) the Blood urea nitrogen(BUN), Serum creatinine(Scr) and endogenous creatinine clearance rate(Ccr);(3) total cholesterol (TC),low density lipoprotein (LDL-C), and other changes.Results8weeks after treatment, there was a very significant difference (P <0.01) between two groups of the total efficiency in treatment.4,8weeks after the treatment group improved significantly, syndromes, and treatment of anterior syndrome scoring more significant or very significant difference(P<0.05orP<0.01), and a control group of syndromes of integral comparison of a very significant difference(P<0.01). Improvement of renal function, the treatment group Ccr were from the beginning of the4week improvement compared with before treatment, there were very significant differences (P<0.01);8weeks after treatment, the treatment group, BUN, Scr, Ccr compared with the control group, there was very significant difference (P<0.01), two groups of Scr, Ccr and the difference contrast before treatment is also a significant difference (P<0.05or P<0.01). At the same time, the treatment group TC from the beginning of the4week were improved, compared with before treatment had significant difference(P<0.05);8weeks after treatment, the difference of the two groups LDL—C compared before treatment had significant difference (P<0.05).ConclusionBengdawan Compound in the treatment of CRF has better curative effect.