Clinical Features And Amalgamative Infection Risk Factors Of Decompensate Cirrhosis Of The Liver Function

Purpose:Liver cirrhosis hepatic decompensation period are clinical frequently-occurring diseasesand common diseases, it is a serious threat to people’s health and life, the mortality rate ishigh, the cause of death for patients with multiple complications, including bleeding of theupper digestive tract, hepatic encephalopathy, hepatorenal syndrome, one of the mostcommon is infections, it is also caused by cirrhosis of liver function decompensated othercomplications are important factors. Liver function of patients with decompensated livercirrhosis infection rate is very high because of liver dysfunction leading to the associatedimmune deficiency, its clinical symptom is not typical, through the understanding of livercirrhosis decompensation period complicated with infection characteristics analysis of livercirrhosis, hepatic decompensation stage combined with risk factors for infection, in order toreduce the occurrence of infection rate, improve the quality of life of patients to provideimportant basis.Method:Collected in our hospital in2010January~2012January gastroenterology during casescomplete hepatic cirrhosis decompensation of liver function in patients of224cases.Recording their general condition, laboratory examination and prognosis. The medicalhistory, symptoms, biochemical examinations, imaging examinations were consistent withliver cirrhosis decompensation period diagnostic criteria.224cases of cirrhosis of liverfunction of patients with decompensated according to whether the infection is divided intoinfection group and non infected group. Application of SPSSl6statistical software packagesfor the possible risk factors of non continuous variables were unconditioned LogistiCregression analysis, calculated the odds ratio (OR), the P value. Measurement data of twosample mean compared with t test, count data in two was compared using the chi-squaredtest method. With alpha=0.05for the inspection level.Result:In this paper224cases of patients with decompensated liver cirrhosis of liverfunction,105cases with infection, infection rate was46.88%, with community infection. Inthis paper, information non infection group119cases of cirrhosis of liver function of patients with decompensated killed6people, the case fatality rate5.04%, infection group105patients died in17, the fatality rate was16.19%, two groups of mortality compared to P <0.05there is significant difference between the two groups, mortality, with reference to theresults indicated the cirrhosis of liver liver function failure decompensated patients notinfected group case fatality rate is lower than the infection group.This study revealed liver cirrhosis decompensation period of infection occurred mainlyin the respiratory tract and abdominal cavity infection is most common, followed by urinarytract, digestive tract, biliary tract, skin and soft tissue infections, hospital infection withabdominal infection common, community infection in respiratory tract infections are morecommon. In105patients with cirrhosis of liver function in decompensated patients from thesite of infection were isolated from11strains bacteria. Among42strains of urine culture ofsputum culture,16strains of pathogenic bacteria of gram-negative bacilli6isolates,7grampositive coccus,5strains of fungi. The above results indicate that infection withgram-negative bacteria, E. coli is dominant, fungi also account for a large proportion of.In this paper,41cases of liver cirrhosis hepatic decompensation stage combined withinfection in patients, fever in19cases, accounting for46.34%, Routine blood white bloodcells (WBC) comparise with admission WBC，white blood cell (WBC) of14casesincreased, accounting for34.15%, of which8cases of fever; WBC was normal in18cases,accounting for43.90%,9fever; WBC decreased in9cases, accounting for21.95%,2cases offever. The results showed that liver cirrhosis decompensation stage combined with clinicalsymptoms of occult infection, fever and leukocyte count growth is not typical.According to liver cirrhosis decompensation stage combined with risk factors forinfection conditions of Log1stic regression analysis, OR size down as follows: age (OR4.014P <0.001), gastrointestinal bleeding (OR2.833P:0.012<0.05), liver function grade C(OR2.659P:0.002<0.05), The length of time the time in the hospital（OR1.049P：0.021<0.05）,according to the infection group and non infected group continuously variable x2test, infection group was obviously lower than that of albumin (ALB) infection group,white cell count on infection group was significantly higher than that of the infected group,prothrombin time infection group longer than the infection group.Conclusion：Liver cirrhosis hepatic decompensation period with high incidence of infections of46.88%, community infection. Infection occurred mainly in the respiratory tract andabdominal cavity infection is the most common, are not the typical clinical symptoms. Cirrhosis of the liver function of patients with decompensated uninfection group case fatalityrate is lower than the infection group. Effects of cirrhosis hepatic decompensation periodcomplicated with infection to a variety of factors, were age, gastrointestinal bleeding, liverfunction grade C. Early detection and timely treatment of liver cirrhosis decompensationperiod complicated with infection, can reduce the incidence of infection and mortality ofpatients, improve the quality of life of patients.