| Objective: As known as the transaction of cervical sympathetic trunk canhave the protective effect of focal cerebral ischemia, we explore therelationship with the protective effect of focal cerebral ischemia, the solubleNSF protein attachment protein (SNAPs) receptor (the SNARE) and ischemicbrain injury.Methods:130Wistar female rats were divided into the middle cerebralartery occlusion group (model group) and the middle cerebral artery occlusionline with the transaction of cervical sympathetic trunk group (treatment group)randomly. According to the embolization time, every groups were divided into6hours,24hours,48hours and72hours of four subgroups. Middle cerebralartery of occlusion (MCAO) model in the brain of Wistar rats were using thesuture method. Based on this model, we make the transaction of cervical ofsympathetic trunk (TCST) to simulate the human satellite ganglion block(SGB). Observe the impact of general status and nerve function of theexperimental rats with TCST. Applicate the immunohistochemical stainingmethod to observe soluble N-ethylmaleimide-sensitive fusion protein (NSF)protein attachment protein receptors (the SNARE) activity in the hippocampalCA1region in each group at each time point in rat brain tissue cellsResults: The general state (neurological score) of the treatment group andsurvival was significantly better than the control group, while rats SNAREexpression was significantly higher than the model group.Conclusion: The transaction of cervical sympathetic trunk make that theSNARE expression was significantly increased, thereby improving the generalstatus and the survival rate of ischemic stroke in animals, have a protective effect on focal cerebral ischemia. These effects of TCST may be throughSNARE-mediated pathway, and provide a strong experimental basis for theclinical use of stellate ganglion block in treating ischemic stroke. |
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