Effects Of Propofol And Sevoflurane On Cerebral Oxygen Saturation During One-lung Ventilation

Objective:To investigate the effects of propofol and sevoflurane and one-lung ventilation time on cerebral oxygen saturation Methods: According to the ASA classification, we choose58patients who belong to ASA Ⅰ-Ⅱ and seperate them in two groups randomly. Each group contains29patients. Both of these two groups accept the same derivatives. In group P, using propofol TCI3.5-4.0ug/ml for maintenance anesthesia,while in group S, using1.7%-2%sevoflurane. Recording and evaluating the general situation,fluid transfusion and blood loss of each group of patients and rSO2, PaO2, PaCO2, Hb, MAP values at TLV、OLV15min, OLV30min, OLV45min, OLV60min.Results:There is no significant differences in general situation between the two groups(P>0.05).Comparing between group P and group S, the values of rSO2、 PaO2、PaCO2have no significant differences at any observing time point(P>0.05).In group P, the values of PaCO2, Hb, MAP show no significant difference between TLV and any time after OLV(P>0.05). At any point of time after OLV, the values of rSO2、 PaO2show significant differences compared with TLV (P<0.05). After OLV lasts for30and45minutes, the values of rSO2show no significant difference compared with the moment of15minutes after OLV(P>0.05).But at the time of OLV60min,the value of rSO2show significant difference compared with OLV15min (P<0.05). The same results are also observed in group S. As time of OLV lasts longer, the curve of rSO2show descending trend in both of the two groups. Conclusions:Propofol and sevoflurane are used in maintenance anesthesia for surgical patients who need OLV, the values of rSO2, PaO2, PaCO2, Hb, MAP show no significant difference between these two drugs.OLV60min versus TLV,OLV60min versus OLV15min,the value of rSO2show significant difference.