| Large numbers of clear avidances indicate that there is a threatening increase ofdiabetes worldwide, especially in developing countries. Being one of the major and severechronic complications of diabetes, diabetic retinopathy (DR) ranks among the top four eyediseases along with cataract, keratopathy, gluoma that can deprive one’s eyesight. Indeveloped countries, DR has become the most commen cause of blindness among adults.Wisconsin epidemiologic study of diabetic retinopathy reveals that36and16out of everyone thousand type1and type2diabetes patients become blind respectively. At present thereare37million blind people all over the world and at least4.8%of them are due toproliferative diabetic retinopathy (PDR), when it comes to the group aged less then30, thepercentage jumps up to86.0%. Because of its high prevalence and poor treatmenteffectiveness in late stage, DR brings great disaster to the patients and their family. Soemphasis should be put on the discovering and controlling of the risk factors to prevent DRonset or its progression to severe stage in clinical practice. Present study aims to discover thepotential risk factors through retrospective case analysis of inpatients.Method: Continuous sampling was performed from the entire cases between Feburary2011to August2011on the basis of inculusion and exclusion criteria. The whole set of datacollected was composed of general information, physical examination results, laboratorydata and other assistant examination results. Statistical analysis was carried out withSPSS16.0software. Numerical variables of normal distribution were expressed as mean±SD，while those of non-normal distribution as median(quartile). T test and one way ANOVAwere performed to compare means of normally distributed variables. Non-parametric testwere used in variables of non-normal distribution and categorical variables were analysed byΧ2test.Simplified indipendent factors that represents original variables were extractedthrough factor analysis,and binary logistic regression were performed using these newlydefined variables.Result:1. DR prevalence: Total318cases were included in this study, with43.1%(137cases) being DR (NPDR40.9%, PDR2.2%). NPDR accounts for94.9%of DR while PDRonly for5.1%.2. Comparison of general conditions: There were56.4%(102) males in NDRgroup and43.1%(59) in DR group, OR value is1.707. The mean age of subjects in DRgroup is56(49.0~63.0) with mean diabetic duration of8（3.0~12.0)years，while in NDR group they are51±11.56and2years(0.3~6.0). Subjects with hypertension accounts for40.1%(55) and25.4%(46) in DR and NDR group respectively.3. Comparison of physicalexamination and labolatory data: Mean blood pressure of NDR is130(120~150)/85(80~90)mmHg while in DR it is140(129~160)/90(80~100) mmHg. Thereis unexpected result on mean body weight,74.1±13.4Kg and68.3±11.6Kg in NDR and DRgroups, with statistical significance. Mean UAE value is25.7(18.70~42.08)mg/l in NDR and31.9(19.85~192.28)mg/l in DR. Urine total protein is316.8(175.6~499.0)mg/day and442.0(184.8~782.0)mg/day in two groups. RBC, Hb, Hct are lower in DR group comparedto NDR—RBC (4.53±0.48)×1012/L and (4.72±0.39)×1012/L, Hb131(120~143)g/L and136(128~144)g/L.Hct39.8±4.1%and41.0±3.0%only among women patients.4. Threeindependent factors were extracted through factor analysis, they are protein uria factor, bloodpressure factor and time factor. After performing logistic analysis, they all came out to berisk factors for DR, OR value is4.69、1.741and1.717respectively.Conclusion:1.318subjects with mean diabetic duration of4.0years were included inthis study.43.1%was diagnosed as DR and it is similar to previous reports. While only2.2%comes out to be PDR, lower than other studies.2. Diabetes duration, age, hypertension,proteinuria are demonstrated as risk factors.3. No differences of blood glucose control status,blood lipide level, diabetic peripheral neuropathy and vascular disease were found. |
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