| A lot of evidence shows that breast cancer originated in a tumour-initiating cells, namely "breast cancer stem cells", breast cancer stem cells tohave unlimited differentiation capacity and abnormal proliferation ability. Andall kinds of treatment to foreign lack of sensitivity, even if all sorts of newtreatments joint did not improve survival in patients with breast cancer andprognosis, a series of reports prove aldehye dehydrogenase1can be used asbreast cancer stem cells ideal markers, and for the treatment of breast cancerhas provided a new way. This study is used to immunohistochemicalexperiment method to2003-2010in jilin university hospital breast surgeryBethune first surgery100cases had lymph node of cancer metastasis of patientswith breast cancer pathological specimens experiment study to understandaldehye dehydrogenase1in the expression of cancer metastasis lymph nodes,explores the relationship between the expression and survival, in order to guidefuture breast cancer treatment.Purpose:ALDH1research in cancer metastasis the expression and axillary lymphnode dissection ALDH1expression and survival relationshipMaterials and methods:Collect in2003-2010in jilin university Bethune between the first hospitalsurgery, and breast surgery proved to have a lymph node of cancer metastasis115patients with breast cancer, through the breast surgery after tumor patientfollow-up system registration, eliminate information incomplete in15cases,finally in100patients with.98cases with women, men in2cases, onset ages17years old to77years old, median age58years of age, and follow-up time10-86months and the median follow-up of45months. The application of R&D Systems company to preview human ALDH1antibody (goat), Beijing unlinedupper garment company PV jinqiao-9003goats allergic ldpe-g-nvpimmunohistochemical detection reagent, through the immunohistochemicalldpe-g-nvp for experiments. After the experiment slice of by two experienceddoctors pathologists read a slice. The statistical software SPSS18.0thestatistical analysis of the data, the difference between groups data compares thechi-square test, survival analysis using Kaplan-Meier analysis method and thelog-rank testing method. All the statistics data to (P <0.05) with a statisticalsignificance.Results:ALDH1express46cases (46%), through the will ALDH1expression andage, tumor size, menstrual history, family history, pathologic stage, regionallymph node metastasis, ER, PR, special genetic marker, known as her2etc toperform a chi-square analysis, found that the results are not significant (P>0.05). Survival analysis found that ALDH1express group of survival timeslightly lower than ALDH1negative groups, but between two groups wasstatistically significant (P>0.05).Conclusion:1. Breast cancer axillary lymph node dissection ALDH1expression oftransfer and ER, PR, special genetic marker, known as her2no correlation.2. Breast cancer axillary lymph node dissection ALDH1expression oftransfer with the patient survival time no correlation.3. Breast cancer axillary lymph node dissection ALDH1expression oftransfer has nothing to do with breast cancer prognosis. |
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