| Background:Coronary heart disease(CHD) have the gender difference.In past,scientistsbelieved that the prevalence and incidence of CHD at all ages tends to be higher in malesthan in females,so the participants only included in the early clinical studies andexperiments.But the results from that researches were used into guide the therapy to theCHD of the general population. The typical symptoms of CHD in the medical textbooks aremore universal in female.Because of the difference between male and female with morbidphysiology,just using the coronary angiography to diagnose CHD is far fromenough.Myocardial perfusion imaging can determine not only coronary flow but also themyocardial viability or metabolism,it may make up the defects of coronary angiography.Objective: Applying MPI to investigated whether the symptomatic female patientsaffect the coronary microvascular ischemia.Methods:From January2011to January2012,2459patients with the coronary arteryangiography were hospitalized in cardiovascular department of the China-Japan UnionHospital who were suspected coronary heart disease.The object consisted of46women, aged33～77years(mean age57.0±10.0years),who hospitalized in the period from January2011to January2012.All patients were suspected to CHD but without the obstructive lesions onCAG. We collected the family history of coronary heart disease,smoking, hypertension,diabetes,plasma glucose,hemoglobin,serum uric acid,bilirubin and blood lipids to assess therisk of CHD.Underwent the MPI to determine whether the coronary microvascular ischemiaexisted.All data were analyzed by statistical software SPSS17.0.Result:Among2459patients,there were1014females and1445males.53.45%offemales was obstructive lesion、17.85%was nonobstructive and28.70%was withoutobstructive lesion.67.13%of males was obstructive lesion、15.09%was nonobstructive and17.79%was without obstructive lesion.There was1512patients were obstructivelesion,35.85%of them was females;399patients were nonobstructive,among them45.36%was females;and548patients were normal,53.10%was females.According to the results of coronary angiography, the46cases are divided into normalgroup and non obstructive lession group.The normal group includes22cases(mean age 53.4±11.6year) with5cases of hypertensive (22.7%),2cases of diabetes mellitus(9.1%),9cases of hyperlipidemia(40.9%). The nonobstructive lesion group includes24patients(meanage60.3±7.1years) with11cases of hypertensive(45.8%),5cases of diabetesmellitus(20.8%),14cases of hyperlipidemia(58.3%).Age were significantly differentbetween the two groups(P=0.017).The rates of hypertension,diabetes and hyperlipidemiawere higher in the nonobstructive lession group than in the normal group,but there was nostatistical difference.The total cholesterol levels,low density lipoprotein cholesterol levels and triglycerideslevels in nonobstructive lesion group was higher than that in normal group(5.03±1.08mmol/L vs4.58±0.82mmol/L;3.21±0.88mmol/L vs2.87±0.73mmol/L;1.62±0.65mmol/L vs1.15±0.52mmol/L),among them the triglycerides level was statisticallydifferent.In addition,the total bilirubin,direct bilirubin and indirect bilirubin was lower innonobstructive lesion group than there in normal group(13.9±4.3umol/L vs14.8±4.8umol/L;4.6±0.8umol/L vs4.8±1.0umol/L;9.2±3.8umol/L vs10.0±3.2umol/L),but there were nosignificant difference either.The result of myocardial perfusion imaging in two groups were all negative.Conclusions:1.Characteristics of coronary lesions in female differs from the male,nonobstructivelesions or normal object is more than male,and obstructive lesions is less than male.2.The result of myocardial perfusion imaging in both groups were all normal.It`sconsidered with young age and the few risk factors. |
PDF Full Text Request