| The Prostate cancer (PCa) is a malignant tumor which derives fromprostate epithelial, accounting for4%of genitourinary tumors. And it is one ofthe common malignant tumors in elderly men. Its incidence obviously differs indifferent regions. The incidence of PCa is much higher in the U.S and Europe.Although the incidence in China is much lower than that in the U.S. andEurope, it is increasing largely in China during the last three decades withrelation to many of factors, such as aging of the population and advancing indiagnostic technology, and so on. Screening out for the early prostate cancer inChina is not universal, so most of patients have reach to the late stage of theprostate cancer who often have not a good chance of surgery which can curethe PCa well. The endocrine therapy is the first for these patients. Maximumandrogen blockade (MAB) therapy has become the first-line treatment ofadvanced prostate cancer. The Gleason classification which is an indicator ofmeasureing the degree of differentiation of PCa have the advantages whichinclude simpleness and good relativity in histology. So the Gleasonclassification has been widely applied in clinical. And biopsy specimens fromprostate cancer patients who have received endocrine therapy is onlypathological date. This study aimes at exploring the correlation between theGleason score (GS) of different biopsy specimens and pretreatment serumprostate-specific antigen (PSA) levels, the MAB treatment, in order to providerelated information for diagnosis and clinical treatment of the prostate cancer.The study includes51cases of patients who have reach to the terminalperiod of the prostate cancer.25cases of them receive castration by surgery andthe anti-androgen drug(that is bilateral orchiectomy and the non-steroidalantiandrogen drug named flutamide). And26cases are treated by castration which needs medication and the antiandrogen drug (that is the goserelin jointnon-steroidal anti-androgen drug named bicalutamide).Then respectivelymonitor the levels of serum prostate specific antigen determination of thesepatients at the time when is pre-treatment,3months and6months aftertreatment.We found that:(1)23cases are effective in the the group which receivedsurgical castration and the anti-androgen drug treatment and the efficiency is92%.22cases are effective in the the group which treated by medical castrationand the antiandrogen drugs that the efficiency rate is84.6%. There is nosignificant difference between the two groups.(2) The levels of the serum totalPSA in the three groups by GS is not statistically significant at the time when ispre-treatment,3months and6months after treatment.Therefore, we come to the conclusions from our study:(1) there is nosignificant difference between the two groups that received surgical castrationand the anti-androgen drug treatment and treated by medical castration and theantiandrogen drugs.(2) The correlation is not significant between the differentGS obtained from biopsy specimens and the maximum androgen blockagetreatment. |
