Observational Study On Immunization Effectiveness Of Hepatitis B Vaccine For1-20Years

Objective:In order to understand the positive rate of the protective antibodies and the infection rate of HBV in those people who vaccinated by the blood-borne hepatitis B vaccine and the hepatitis B recombinant yeast-derived vaccine, and to comprehensively evaluate the long-term protective effect and Immune persistence of hepatitis B vaccine in Qinghai province, the investigation were been conducted to provide scientific basis for the hepatitis B vaccine immunization strategies.Methods:Cluster sampling were used in Chengxi,Datong of Xining city and Tongde county. Each county randomly selected at least three communities (towns) or villages for the survey site. The children birthed in1989-1997who had been vaccinated with blood-borne hepatitis B vaccine and the children birthed in1998-2008who had been vaccinated with hepatitis B recombinant yeast-derived vaccine at the newborns were selected to check their hepatitis B vaccination history,and then to carry out epidemiological investigation and blood sampling under the premise of informed consent. The general information about age, gender, nations, et al and the Family histories, the past medical histories of HBV and the hepatitis B vaccination history were all collected by the questionnaire that was designed in advance. Each object were collect5ml blood to test the HBV markers about HBsAg, anti-HBc and anti-HBs by the Microparticle Enzyme Immunoassay. The basic elements of the case questionnaire, reviewed test results and other information were double entered in the Access database. All datas used the SPSS13.0software for the statistical analysis.Results:2056subjects were given epidemiologicial investigation and blood sampling.The positive rate of HBsAg in these children birthed in1989-2008was2.33%, the average positive rate of Anti-HBc and the total infection rate of HBV were5.37%and5.44%. The average positive rate of Anti-HBs of the children vaccinated with blood-borne hepatitis B were57.29%after13-20years, and whether the positive rate of Anti-HBs or the Geometric Mean Concentration of anti-HBs was decreased with years. The average positive rate of Anti-HBs of those children who vaccinated with hepatitis B recombinant yeast-derived vaccine was74.78%. The positive rate of anti-HBs and Geometric Mean Concentration of anti-HBs were standed at higher level after12years.The multivariate logistic regression showed that nation, family members of Hepatitis B patients and age were the risk factors of Hepatitis B virus infection of adolescents. The first dose of hepatitis B vaccine in a timely manner was the protection factors for HBV infection. Conclusion:The average positive rate of Anti-HBs of the children vaccinated with hepatitis B vaccine maintained at above40%after20years, it shows the hepatitis B vaccine has a good immune persisitence. The infection rate of HBV in the vaccined population was not increased with years, and the positive rate of HBsAg revealed significant reduction compared with the teenagers in the epidemiological study on viral hepatitis in1992. Whether the blood-borne hepatitis B or the HepB recombinant yeast-derived vaccine, the long-term immune effects were satisfactory as well as the protective effect of vaccine.