Clinical Evaluation Of Different Doses Of Xuebijing On Sepsis

ObjectiveTo evaluate different doses Xuebijing injection through testing IL-18, PCT, CRP levels and APACHE Ⅱ scoring of the septic patients after treatment.Methods68hospitaled patients were selected who were hospitaled intensie care unit (ICU) over14days in August2010to June2011in the First Affiliated Hospital of Zhengzhou University and consistenting with diagnostic criteria of the2001American College of Chest Physicians/Socirty of Critical Care Medicine(ACCP/SCCM) joint meeting in Washington, DC, finally63patients materials were completed. Our patients were divided into four groups using random method which is:control group contained19cases (Group A), low dose group20cases(Group B, Xuebijing injection100ml/day), medium dose group14cases(Group C,Xuebijing injection200ml/day), high dose group10cases(Group D,Xuebijing injection400ml/day). Patients of were all treated with conventional Western treatment which including pathogeny cure, antibiotics, ventilator support, rehydration, nutrition support, maintain electrolyte balance, etc, patients of low dose group, medium dose group and high dose group were injection xuebijing injection additional. Our patients’ vital signs (including body temperature, breathing, pulse and blood pressure). blood routine and liver function, kidney function, electrolyte, coagulation function, IL-18, PCT, CRP and APACHE Ⅱ score) were recorded before treatment (XO) and after3days (X3),7days (X7),14days (X14) after xuebijing injection. At the previous four points, we taken3ml venous blood, placed in1.5ml EP stored in-70℃refrigerator after centrifugal, detected the serum IL-18concentration with ELISA test. At the same time recorded the condition of every patients in14days. Finally the different effection before and after the treatment with on sepsis with Xuebijing was statisticed through SPSS17.0.Results1. Age, gender, vital signs (including body temperature, breathing, pulse and blood pressure), blood routine and liver function, kidney function, electrolyte, coagulation function, IL-18, PCT,CRP and APACHE Ⅱ score of four group have no statistical significance (P>0.05).2. control group (Group A):Vital signs (including body temperature, breathing, pulse and blood pressure), blood routine and liver function, kidney function, electrolyte, coagulation function which through conventional western medicine treatment method after14days were statistical significance (P<0.05), inflammatory factor (IL-18, PCT, CRP) and APACHE Ⅱ score after treatment7days were statistical significance (P<0.05).3. Low dose group, medium dose group and high dose group:The change of vital signs (including body temperature, breathing, pulse and blood pressure), blood routine and liver function, kidney function, electrolyte, coagulation function degress and dose is negative correlation, have statistical significance (P<0.05).4.Low dose group:Inflammatory factor (IL-18, PCT,CRP)and APACHE II score are treating after7days, have statistical significance (P<0.05), after14days which have statistical significance (P<0.01). Comparison among groups, low dose group compares with control group after14days which have statistical significance (P<0.05).5.Medium dose group:Inflammatory factor (IL-18, PCT,CRP) and APACHE II score are treating after3days, have statistical significance (P<0.05), after14days which have statistical significance (P<0.01). Comparison among groups, medium dose group compares with low dose group after3days which have statistical significance (P<0.05), compares with low dose after14days which have statistical significance (P<0.01).6. High dose group:Inflammatory factor (IL-18, PCT, CRP)and APACHE Ⅱ score are treating after3day, have statistical significance (P<0.05), after7days, which have statistical significance(P<0.01). Comparison among groups:high dose group compares with medium dose group after3days which have statistical significance (P<0.05), compared with low dose after7days which have statistical significance (P<0.01).7. accumulative survival rate of the control group, low dose group, medium dose group and high dose groups were used Kaplan-Meier analysis during14days: the cumulative survival rate of four groups of patients with sepsis with gradually increased with time.ConclusionsHigh dose Xuebijing injection was given to patients with sepsis in early phase helps to temperature, heart rate and white blood cell level; mediate microcirulation and oxygen metabolic disorders, control the inflammatory response to blocking SIRS turn to MODS; protect the viscera function and improve blood coagulation, at the same time, improve septic patients14days cumulative survival rate.