The Changes And The Clinical Significance Of Vascular Endothelial Cadherin And Hypersensitive C-reactive Protein In Patients With Coronary Heart Disease

Objective To explore the changes and clinical significance of serum vascular endothelial cadherin (VE-cadherin) and hypersensitive c-reactive protein (hs-CRP) levels in patients with coronary heart disease (CHD). Methods By using enzyme-linked immunosobent assay (ELISA), serum VE-cadherin and hs-CRP were measured in20patients with acute myocardial infarction (AMI),20patients with unstable angina pectoris (UAP),20paitents with stable angina pectoris (SAP) and20controls. Results The serum levels of VE-cadherin, hs-CRP in the patients with CHD were higher than those in the controls (t=6.02,6.27, P<0.01). VE-cadherin and hs-CRP levels were gradually increased in SAP group, UAP group and AMI group. There were significant differences in the serum levels of VE-cadherin and hs-CRP among the AMI, UAP and SAP patients (F=35.66,36.12, q=4.56～9.83, P<0.01). The levels of VE-cadherin and hs-CRP in CHD patients were positively correlated(r=0.507,.P<0.01). The area under the ROC curve (AUCROC) of VE-cadherin and hs-CRP were0.975,0.988, and the sensitivity and specificity of VE-cadherin and hs-CRP were0.95,0.90and0.95,0.95in patients with AMI. The AUCROC of VE-cadherin and hs-CRP were0.915,0.956, and the sensitivity and specificity of VE-cadherin and hs-CRP were0.90,0.J5and0.90,0.95in patients with UAP. The AUCROC of VE-cadherin and hs-CRP were0.801,0.813in patients with SAP. VE-cadherin, hs-CRP for AMI, UAP patients have a high diagnostic value, and have no statistical difference (u=0.357,0.195, P>0.05). Conclusion The elevated serum levels of VE-cadherin and hs-CRP might be closely associated with the degree of coronary artery condition, which might be had a highly diagnostic value on CHD.