| Purpose:The research project is to explore the relationship between aging and constitution, and to guide the application of Qiongyu Gao on anti-aging and constitution regulating based on a series of investigations. Furthermore, to enrich the contents of aging and anti-aging, and to lay the foundation for clinical research and later scientific research of ancient Qiongyu Gao.Methods:We carried out an investigation on aging factors, syndrome and TCM constitution aimed at the population which is more than thirty-five years old in Guangzhou. Built on understood of the literatures on aging and TCM constitution, we got the relativity between aging and constitution type with the accurate statistical analysis. Besides, Qiongyu Gao was applied to the selected crowd, clinical outcome measurement was executed by the scores of aging syndrome before and after the treatment, ultimately to evaluate the anti-aging effects of Qiongyu Gao.Results:Analyzed from the general conditions, there was a significant statistical revelation between age and aging degree according to Chi-square test(P<0.01). Likely, there was a significant statistical revelation between BMI and aging degree (P<0.01). However, there was no significant statistical revelation between gender and aging degree (P>0.05).Analyzed from the habits and customs, there were significant adverse effects on aging degree in smoking (P<0.01) and burning the midnight oil (P<0.01). In contrast, there were significant favorable effects on aging degree in physical exercise (P<0.01). However, there were no significant effects on aging degree in drinking (P>0.05) and somnus(P>0.05).Analyzed from Body Mass Index (BMI), stepwise mul tiple regression anal ysis was implemented between BMI and nine kinds of constitutions. There was correlation between BMI and phlegm-dampness constitution, the corresponding multiple correlation coefficient R=0.31, coefficient of determination R2=0.07. Analysis of variance (ANOVA) was implemented on partial regression coefficient once variables were brought in, F=3.79, P<0.01.Analyzed from the habits and customs, there were significant adverse effects on aging degree in smoking (P<0.01), however, there were no significant effects on aging degree in drinking (P>0.05). Stepwise multiple regression analysis was implemented between drinking and nine kinds of constitutions simultaneously. There were correlations between drinking and phlegm-dampness constitution, damp-heat constitution and blood-stasis constitution. ANOVA was implemented on partial regression coefficient once variables were brought in, F=10.86, P<0.01. There were significant favorable effects on aging degree in physical exercise (P<0.01), there were no significant effects on aging degree in somnus (P>0.05). Stepwise multiple regression analysis was implemented between burning midnight oil and nine kinds of constitutions. There were correlations between drinking and yin-deficient constitution, damp-heat constitution and blood-stasis constitution. The corresponding multiple correlation coefficient R=0.71, coefficient of determination R2=0.51. ANOVA was implemented on partial regression coefficient once variables were brought in, F=35.91, P<0.01.Analyzed from the constitution, there were significant effects on aging degree in constitution according to Chi-square test (P<0.01). Nine kinds of constitutions were defined as independent variables, correspondingly the aging score as the dependent variable in the stepwise multiple regression analysis. There were correlations between aging and normal constitution, qi-deficient constitution, yang-deficient constitution, yin-deficient constitution, phlegm-dampness constitution and qi-depression constitution. ANOVA was implemented on partial regression coefficient once variables were brought in, F=63.01, P<0.01.Analyzed from the anti-aging and constitution regulating of Qiongyu Gao, before the treatment, the scores of experimental group were all similar to the control group (P>0.05). The scores of experimental group which were measured before and after the treatment were compared, the P values of aging degree, qi-deficient and yin-deficient were all P<0.01, moreover, the P values of normal, yang-deficient, phlegm-dampness, damp-heat, and blood-stasis were P<0.05, nevertheless, as to qi-depression, and specific endowment constitution, P>0.05. The scores of control group which were measured before and after the treatment were compared, the P values of aging degree, normal, qi-deficient, yin-deficient, yang-deficient, phlegm-dampness, damp-heat, blood-stasis, qi-depression and specific endowment constitution were all P>0.05. The experimental group was superior to the control group in aging degree, qi-deficient and yin-deficient (P<0.01). The both group were uniform in normal, yang-deficient, phlegm-dampness, damp-heat, blood-stasis, qi-depression and specific endowment (P>0.05).Conclusions:The results in this study showed that there were significant effects on aging degree in aging, smoking, physical exercises, burn midnight oil and BMI. This indicates that we should pay attention to health preservation, smoking and burn midnight oil should be completely eradicated, besides, more physical exercises should be needed to control body weight. Among all kinds of influencing factors, there was a correlation between BMI and phlegm-dampness constitution. Drinking was correlative with phlegm-dampness constitution, damp-heat constitution and blood-stasis constitution. There was a negative correlation between drinking and blood-stasis constitution, in other words, drinking could decrease the incidence rate of blood-stasis syndrome. Burning midnight oil was correlative with yin-deficient, damp-heat and blood-stasis constitution.The relevance was ranked from high to low in this study, respectively yin-deficient, qi-deficient, normal, yang-deficient, phlegm-dampness and qi-depressed. Above all, yin-deficient and qi-deficient were the top factors on aging degree.There was a negative correlation between normal and aging degree, that’s to say, a individual with normal constitution was easier to keep healthy. The positive correlation between aging and qi-deficient, yin-deficient, yang-deficient, phlegm-dampness and qi-depressed indicated that although constitutions were the specific sign of the relatively stable physiology, they were to be regulated because of the disadvantages to longevity,The anti-aging effects of Qiongyu Gao was demonstrated again in this study. Qiongyu Gao could significantly regulate qi-deficient, yin-deficient, yang-deficient and blood-stasis to normal. Conversely, the opposite effects were found in phlegm-dampness and damp-heat constitutions which fit the contraindications of Qiongyu Gao in them. The reason for that might be the greasy medicine which was contained in Qiongyu Gao was trend to heat-transmission. |
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