The Research Of Correlation Analysis Between The Viral Etiology Of The Influenza-like Illness And TCM Syndromes In531Patients

BackgroundInfluenza-like illness is a common disease and frequently-occurring disease, and affects the patient’s quality of life and work to a certain extent.In recent years, it has been a public health problem to everyone. The main modern medical treatment of this disease is symptomatic treatment. Chinese medicine has accumulated rich clinical experience in the treatment of exogenous fever. In recent years, the advantage of Chinese medicine in the influenza-like illness caused by viral infection received widespread attention. Reports in the literature are mainly on the evaluation of the efficacy of some prescriptions in traditional Chinese medicine. But there have been no uniform standards in the TCM Syndrome Differentiation in the influenza-like illness caused by viral infection. And yet, there are few researches Using epidemiological survey methods to study the TCM Syndromes of the influenza-like illness caused by viral infection. Studying the laws of the TCM syndromes of the influenza-like illness caused by viral infection can provide basis for decision making in an effective clinical treatment program, and improve the clinical efficacy of influenza-like illness.ObjectiveThe purpose of this study is to investigate the laws and the TCM syndromes of the influenza-]ike illness confirmed by the viral etiology tests. It lays the foundation for the standardized study of TCM syndromes in multi-centers、 long-term and large samples for a further development. MethodsIn this study, from February2009to September2011, at the fever clinic in the Guangdong Province Hospital of TCM, a total of531cases of influenza-like illness confirmed by viral etiology tests from throat swabs are checked for clinical Epidemiological investigation. The details include gender、age、 evidence of viral etiology、onset time and season、visiting time、Past history、 western medical diagnosis、the highest body temperature、number of visits、 symptoms、signs、laboratory tests and so on. The medical record information will be collected to build the database using the SPSS18.0. The general clinical data and information of four diagnostic methods of the patients with influenza-like illness is analyzed by descriptive analysis method. We sorted all the results by frequency analysis of the TCM information of four diagnostic methods, organized the statistical results combined with clinical, then did the cluster analysis using the tidied TCM information items. By the system clustering method, we did the the sample cluster analysis, extracted the basic TCM syndrome from various types of influenza-like disease of viral infections, gave names to the appropriate syndromes referred to the TCM classification criteria, did the weight calculation of information of TCM four diagnostic methods from various syndromes, analyzed the correlation of the TCM syndromes of influenza-like illness and the viral etiology preliminarily, to summarize clinical operable TCM Syndromes.ResultRetrospective studies showed the basic characteristics of the patients with influenza-like illness confirmed by the viral etiology:1. Influenza-like illnesses of viral infection are more common in young adults,.The incidence have not gender differences, but have seasonal distribution;2. Most patients haven’t special past medical history. Generally their course of disease is in a shorter duration, and the highest temperature is39.0℃or less. About40%patients require the use of antibiotics;3. Most patients infected with the common influenza-A virus, H1N1influenza-A virus and influenza-B virus. The western clinic diagnosis is acute upper respiratory tract infections;4.ILI patients’s symptoms, signs and blood tsets have its specificity. Four kinds of TCM syndromes of influenza-like illness are generalized according to the specificity of four diagnostic information, including the exogenous pathogenic wind syndrome, exogenous cold turning hot syndrome, exogenous wind-heat syndrome and exogenous wind-heat with dampness syndrome;5. The incidence peak of the common influenza-A virus, H1N1influenza-A virus and inf luenza-B virus is seasonal. Three kinds of TCM syndromes by cluster analysis are generalized:exogenous cold turning heat syndrome, exogenous cold turning heat with dampness syndrome, exogenous wind-heat syndrome;6. More than20%of the patients in the three major viral pathogens fulfill the diagnostic criteria of SIRS, while common influenza-A virus have the highest proportion. Infection-inflammation response with exogenous wind-heat syndrome is more severe than other syndromes.ConclusionThe use of mathematical statistical methods to investigate the TCM Syndromes of influenza-like disease of viral infection reflects the organic combination of traditional Chinese medicine theory and modern scientific research methods, and provides relatively objective dialectic references for the clinical diagnosis and treatment of influenza-like illness.