Tcm Syndrome Of Influenza-like Illness And Clinical Efficacy Evaluation Studies

Objective: Improve the influenza-like illness of TCM classification and summarized their characteristics, and optimize the "4:00 cold side" of the group, research the best treatment for the prevention and treatment of influenza-like illness to provide treatment ideas and prescriptions.Study: Based on "clinical diagnosis and treatment of influenza Guide (Draft)" (2002) of influenza-like illness diagnostic criteria and "Chinese medicine, science" (fourth edition) of the line when the cold-hot-cold and wind at the line Cold Syndrome standards, included 120 cases of cases, parallel control, randomized, double-blind design of reference "Chinese medicine clinical research of new drugs guiding principles" (2002), according to Chinese medicine Differential Treatment, treatment three days, the recall of influenza-like illness into a Chinese medicine Permit characteristics, and before and after treatment of Chinese medicine syndrome score and the score to body temperature, using SAS8.0 software analysis results.The results:1. Certification of classification and characteristics:Heat, cold and wind-heat two. Heat, cold characteristics: high fever (more than in body temperature between 39.5-42℃) cold war consisting mainly of non-Han Chu, more Nanren continuing with the muscle soreness, severe headache, neck and bilateral main temple, a slight Yangan pharyngodynia, or see the other weak, nasal symptoms; Hot wind characteristics: fever (more than the body temperature of 39.5 in℃) in non-Han Chu-Wuhan-based disease, with more impact on swallowing the Yangan burning, no sore muscles and headache, or see the other weak, nasal symptoms.2. The two groups after treatment (3 days) compared changes in body temperature Heat, cold-type: According to the group (independent) information t test, P = 1.10, before the trial that the same level as the body temperature of the two groups. According to data matching t-test, treatment group, the control group therapy treatment before their respective comparison group, P <0.0001, a very significant difference, that addition and subtraction Gegentang, Maxing-Gan Tang significantly cooling effect due to treatment and the first two Group same level as the body temperature, it can direct the treatment group (independent) information on the t-test, compared with the results, F = 1.31, P <0.0001, a very significant difference, cooling, addition and subtraction Gegentang group (37.28±0.49) was stronger than in Maxing-Gan Tang group (38.57±0.43).Hot-air: According to the group (independent) information t test, P = 1.16, before the trial that the same level as the body temperature of the two groups. According to data matching t-test, treatment group, the control group therapy treatment before their respective comparison group, P <0.0001, a very significant difference that Jiawei Yinqiaosan, Yinqiaosan significantly cooling effect because the body temperature of the two groups before treatment The same level, it can direct the treatment group (independent) information on the t-test, compared with the results, F = 3.53, P <0.0001, a very significant difference, cooling, the Modified Yinqiaosan group (37.26±0.61 ) Was significantly stronger than Yinqiaosan group (37.97±0.33).3. Clinical comparison because the two groups belonging to individual (effect) in an orderly manner, it can not be used simply X2 test, optional R * C experimental design using SAS software in order to achieve the CMH X2 and P value for statistical analysis. Heat and cold outside the group, CMH X2 = 13.19, P = 0.0003, a very significant difference, that is to alleviate symptoms in the clinical efficacy, addition and subtraction Gegentang group (90 per cent of the total effective rate) is better than Ma Gan Shi Xing Tang Group (The total efficiency of 80 per cent). Hot winds Group, CMH X2 = 6.62, P = 0.083, a significant difference, that is to alleviate symptoms in the clinical efficacy, addition and subtraction Gegentang group (90 per cent of the total effective rate) is better than Ma Shi Xing Gan Tang ( The total efficiency of 70 per cent).4. Safety testing: external heat of the cold during the treatment of patients with a small number of diarrhoea, nausea and adverse reactions, the treatment group and control group, rates were 5.56 percent and 2.78 percent, the difference was not significant (P> 0.05) . Heat and cold external observation of patients during the treatment, also suffered from diarrhoea, nausea and adverse reactions, the treatment group and control group, rates were 4.87 percent and 3.21 percent, the difference was not significant (P> 0.05). And may consider issues related to the quality of traditional Chinese medicine, such as exposed to moisture, such as eradicating corruption. Laboratory: electrocardiogram and no abnormal liver and kidney function.Conclusion: The influenza-like illness of TCM into heat, cold and wind-heat; Modified Gegentang the heat of the cold-cooling effect and clinical efficacy is better than Maxing-Gan Tang; Modified Yinqiaosan the hot wind - Cooling effect and is superior to clinical efficacy Yinqiaosan; two decoction no clinical adverse reactions and side effects.