Clinical Observation On Roasted Radix Puerariae Apply For Point Application Therapy Treating Infantile Rotaviral Enteritis

BackgroundInfantile rotaviral enteritis is caused by rotavirus infect ion acute self-limited disease, which spreads rapidly and widely in June the old to2years old children with the highest incidence, often combined with myocardial damage and different degrees of dehydration syndrome, will caused great harm for the health of infants. At present western medicine treatment of the disease there is no effects of drugs, Chinese herbal medicine in this disease has definite advantage; And point application therapy in the treatment of diseases and adjusting constitution has a long history, and can overcome the difficulties of pediatric oral medications, avoiding the hepatic first-pass effect, through the acupuncture point and sensitivity to play a drug topical therapy, received within the administration, regulating effect. The point application therapy on prescription for drug, dosage and drug resistance cannot be identified, it is difficult to do quality control. The school in the " preventive treatment of disease" under the concept of extensive adjusting constitution and point application therapy, and according to the clinical experience of screening for drugs, acupoint drug research to provide a broad prospect.Object iveThis topic from the commonly used drugs for treatment of infantile diarrhea Kudzu start, through the observation in the conventional treatment on the basis of application with roasted RADIX PUERARIAE for point application therapy on children with rotavirus enteritis in children clinical efficacy and safety of preliminary discuss, with period for treatment of infantile rotavirus enteritis with better drug acupoint sticking, shorten the infantile rotavirus enteritis in the course of the disease, reduce children taking the drug, injections bring the pain.MethodsA prospective randomized controlled clinical trial design method, from January2011to January2012in Nanhai Affiliated Maternity and Children’s Hospital of Guangzhou University of Chinese Medicine, internal medicine, consistent with the diagnostic criteria and the inclusion criteria of infantile rotavirus enteritis in59cases, using a table of random numbers were randomly divided into the observation group with roasted RADIX PUERARIAE and dextrin control group. The two groups were using fluid therapy, gastrointestinal mucosal protective agent, symptomatic treatment and conventional therapy, the observation group with roasted RADIX PUERARIAE acupoint on Shenque point, bilateral Tianshu point and bilateral Pishu points; a dextrin control group with simmer amount of dextrin production into a sticking plaster on Shenque point, bilateral Tianshu point and bilateral Pishu points, the course of treatment is3days. Combined with the scale of two groups were observed in children with stool normal days, before and after treatment of stool frequency, character, fever, vomiting, skin elasticity, perianal skin and other symptoms and signs and symptom scores improved, and the detection of two groups of children with stool rotavirus antigen, myocardial enzymes and other relative laboratory indexes, establish database, use SPSS13. Ostatistic analysis.ResultsThe experimental study of the general information before sex, age, course of disease, syndrome types before admission, observation of the symptoms and signs of syndrome classification and integral and CK-MB detection results and abnormal rate, through statistical analysis, two groups had no significant difference among, comparable. The end of the study, roasted RADIX PUERARIAE observation group of30cases, dextrin29cases in the control group, two groups constitute respectively:20cases, effective in9cases, ineffective in1cases, effective in2cases, effective in21cases, ineffective in6cases, the total effective rate was96.7%; in79.3%, prompting roasted RADIX PUERARIAE observation group in the total efficiency are better than those of dextrin in control group, P<0.05, with a significant difference between two groups; the two groups after treatment in stool normal days after statistical analysis, P<0.05, prompting difference has statistics significance, tips for roasted RADIX PUERARIAE group stool restores the normal time with dextrin controls short; two groups of pulley virus seroconversion rate by chi-square test, P<0.05, with statistical difference, prompting roasted RADIX PUERARIAE observation group in rotavirus negative rate than dextrin controls; by the two groups before and after treatment CK-MB value and abnormal rate comparison, P<0.05, with statistically significant differences, prompting roasted RADIX PUERARIAE observation group in the adjuvant treatment of myocardial damage is superior to control group in terms of dextrin; two groups after the treatment, symptom integral reduction rate by statistical analysis comparison, P<0.05, with statistical difference, prompting roasted RADIX PUERARIAE in the observation group than symptom scores improved paste Fine control group advantage; by observation, no safety index abnormalities and adverse reaction.ConclusionRoasted RADIX PUERARIAE acupoint application can improve the treatment of infantile rotavirus enteritis in the total efficiency, shortening of rotavirus enteritis in children stool restores the normal time, promote the rotavirus antigen, promote the improvement of myocardial damage, promote recovery, no adverse reaction.