Comparison Of Efficacy And Toxicity Between Gp And Np Regiments In Adjuvant Chemotherapy For NSCLC

Background: The regiment of NP is the standard chemotherapy whichis recommended by Evidence-based Medicine, however, the regiments of GPand DP are also recommended by NCCN, besides the regiment of GP is oneof the most commonly used regiments for NSCLC. Compared with theregiment of NP, whether it has a better efficacy and greater safety, which need alarge number of clinical data to be determined.Objective: The object was to compare the efficacy and security of GPand NP in adjuvant chemotherapy for NSCLC, which can help select the betterregiment for NSCLC. The main outcome measured included disease-freesurvival and median disease-free survival and the secondary indicator wasadverse reactions.Methods: The study consisted of73patients discharged between2007Jul and2009Dec,48of them are males,25are females, age between31to71years old, median age56years old. Pathological type:45of them are squamouscell carcinoma,25of them are adenocarcioma,3of them are adenosquamouscarcinoma. Clinical stage:13of them are the stage of Ⅰb,19of them are thestage of Ⅱa,28of them are the stage of Ⅱb,13of them are the stage of Ⅲa.The number of patients which are younger than the age of65years old is63,greater than or equal to the age of65years old is10. The lung CT, routineblood and biochemical were used to assess treatment effects and safety. Themain outcome measured included disease-free survival and median disease-freesurvival and the secondary indicator was adverse reactions. The group data isanalyzed by statistical software.Results: After4cycles of adjuvant chemotherapy by the regiment of GP or NP, we compared the two results of the two groups of patients who acceptedthe complete resection. The disease free survival and median disease-freesurvival of GP group is better than the NP group, and there is significance (P＜0.05). On hematological toxicity, the patients of the two groups who occurredleukopenia, neutropenia and hemoglobin reduced are similar on the number andextent, the difference is not statistically significant (P＞0.05), thethrombocytopenia less in NP group than in GP group, and there is significance(P＜0.05). The patients of the two groups with liver and kidney functionimpairment, nausea and vomiting are similar, there is no significance (P＞0.05). The number of the patients who occurred phlebitis in NP group is greaterthan the GP group, the difference is statistically significant (P＜0.05).Conclusions: For the non-small lung cancers after complete resection,the disease free survival and median disease-free survival of GP group is betterthan the NP group, and there is significance. The thrombocytopenia less in NPgroup than in GP group, but the number of the patients who occurred phlebitisin NP group is greater than the GP group. On hematological toxicity, thepatients of the two groups who occurred leukopenia, neutropenia andhemoglobin reduced are similar on the number and extent, the difference is notstatistically significant. The two regiments are safe to the non-small lungcancers who accept adjuvant chemotherapy and the adverse reactions caused bychemotherapy can be tolerated and reversible. Because of limited number ofcases and observations, a large number of clinical trials need to be done andcollect more clinical data.