Clinical Character And Analysis Of Prognosis Factors Of144Adult Acute Monocytic Leukemia

Objective:To analyze Clinical character and prognosis factors of adult acute monocytic leukemia.Methods:Clinical data of144patients diagnosed between Jan1sht2006to Dec312010were collected.clinical manifestation, cytochemistry, cytogenetics, Immunophenotyping and MRD were analyzed respectively.The numeration data was tested by χ2test, while the measurement data by Levene test to variance homogeneity and by T test to the mean difference. The data was analysis by Excel2010, SPSS17.0softwares.Results:81.9%of144patients reach complete remission.27.5%patients are abnormal in cytogenetics, including+8、-5/del (5q)、-7/del (7q).Patients were devided into three groups according to chromosome karyotype,intermediate prognostic group has better OS and DFS than poor prognostic group (P<0.05).26patients treated with SCT, they have higher OS rate for one year and low relapse rate than not SCT group.CR rate for Old patients (≥55) and young patients (<55) are69.4%and86.1%respectively.Old patients have shorter OS and DFS than young patients,but no significant difference in FAB type,number of white blood cell and Immunophenotyping.Old patients occur chromosome abnormalities more frequently than young patients.Relapse rate is20.7%in MRD+group versus11.5%in MRD-group.Multivariate cox analysis find that chromosome karyotype and MRD have most significant correlation with relapse.Conclusion:Chromosome karyotype,age,therapy,MRD are all prognostic factors of M5.Chromosome karyotype and MRD have most important significance in prognosis.