The Relationship Between Chromosome Karyotype And Induction Success In Acute Myeloid Leukemia

Objective: To get the message of the distribution state of WHO classification of acute myeloid leukemia (AML)in xinjiang uygur autonomous region and explore the effect of chromosome karyotype in the WHO classification of acute myeloid leukemia. Methods: 107 patients with de novo AML who hospitalized in blood branch/ paediatrics, three hospitals of xinjiang uygur autonomous region from 2007 March to 2009 June were collected,who were diagnosed according to WHO classification. The chromosome karyotypes of the patients with AML were observe.The complete remission (CR) rate of induce chemotherapy was compared between subgroups classified. Results: In 107 patients with AML ,there were 36(33.6%) patients with AML with recurrent cytogenetic translocations, 32 patients were chromosome karyotype of favorable risk,4 patients were chromosome karyotype of intermediate risk,there were 24 (22.4%) patients with AML with multilineage dysplasia,17 patients were that of intermediate risk,7 patients were that of adverse risk, there were 47(43.0%) patients with not otherwise categorized AML ,39 cases were that of intermediate risk,8 cases were that of adverse risk. The CR rate of induce chemotherapy of patients with AML with chromosome karyotype of favorable risk was 87.5%, The CR rate of induce chemotherapy of patients with AML with chromosome karyotype of intermediate risk was 45.0%, The CR rate of induce chemotherapy of patients with AML with chromosome karyotype of adverse risk was 26.7%, The CR rate of induce chemotherapy of patients with AML with t(8;21)/AML1-ETO and AML with inv(16) (p13q22)or t(16;16) (p13; q22)/CBFB-MYH11 was significantly higher than that of the patients with not otherwise categorized AML(P<0.05). The CR rate of induce chemotherapy of patients with AML with multilineage dysplasia was significantly lower than that of patients with AML without multilineage dysplasia(P<0.05). Conclusion: The CR rate of induce chemotherapy of AML with favorable risk chromosome karyotype is high.Cytogenetics is among the useful factors predicting attainment of CR in AML.