Simvastatin For Diabetic Rats Palatal Implant Surrounding Bone Tissue BMP-2 Of The Expression Studies

Objective:To investigate the expression and clinical significance of bone morphogenetic protein 2（BMP-2）in bone tissue around the implant after simvastatin intervention.Method:After 1-week adaptive feeding without abnormal condition，40 female adult SD rats were equallydivided into A group（normal control group）and B group（experimental group group）. A groupwas intraperitoneal injected with citrate buffer. B group was intraperitoneal injected withstreptozotocin（STZ）50mg／kg to set up the diabetic rats model.After the model wassuccessfully established，A group and B group were implanted with Titanium in the proximaltibial metaphysic.B group was randomly allocated to B1group（Diabetes Mellitus+ implantgroup）and B2group（Diabetes Mellitus+ implant + simvastatin group）.There were 10 rats ineach group. B2 rats were given orally simvastatin 5mg·（kg-1·d-）；A and B1 rats were givenorally normal saline 1.5ml·（d-1）. After of 12 weeks of feeding the rats were sacrificed.Immunohistochemical technique were used to assess the expression of BMP-2 in bone tissuearound the implant.Results:Positive rate of cells in B2 group was significantly higher than that in B1 group. The differenceis significant statistically（P < 0.01）.Conclusion:Simvastatin can enhance the expression of BMP-2 gene in bone tissue，improve bonemetabolism and implant osseointegration.