Expression Of Adhension Molecule CD146and Microvessel Density In Renal Cell Carcinoma And Its Clinical Signif Icance

Expression of Adhension Molecule CD146and microvessel density in Renal Cell Carcinoma and Its Clinical Signif icanceObjective:To explore the relationship between CD146(MCAM), microvessel density of Renal cell carcinoma and its clinic-pathology, and to explore their correlation with clinicopathologic parameter of RCC.Methods:Immunohistochemisty was employed to determine the expression of CD146and microvessel density (MVD) in43RCC tissues and normal renal tissues. With anti-CD146McAb(monoclonal antibody) and anti-CD34McAb,immunohistochemistry was used to study the expression of CD146and the tumor MVD in43cases of RCC and in20cases of normal renal tissue as controls.Results:The positive expression of CD146in renal cell carcinoma tissue (90.70%) was remarkably higher than that normal renal tissue(30%)(P<0.0001)。The expression of CD146was not correlated with category of renal cell carcinoma(χ2=1.3713)(average P>0.001), contrasting to the tumor volume(χ2=7.5701) and significant correlation to clinical stage(r=0.61616) and metastasis of renal cell carcinoma(χ2=19.9898)(P<0.001)。The MVD of renal cell carcinoma tissue (78.00±23.10/200HP) was significantly higher than that of normal renal tissue (3.05±7.93/200HP), The MVD of CD146was not correlated with the tumor volume (t=1.33) and category of renal cell carcinoma (t=1.46)(average P>0.001), contrasting to significant correlation to clinical stage (t=2.37) and metastasis ofrenal cell carcinoma (t=2.10)(P<0.001). There was a positive correlation between expression of CD146and MVD in renal cell carcinoma(r=0.74482, P<0.0001).Conclusion:The overexpression of CD146in renal cell carcinoma have a significant relation with tumor angiogenesis. The expression of CD146and angiogenesis might serve as an important indicator of malignancy the development, progress and metastasis of renal cell carcinoma.