Relationship Between Serum Resistin And Intrauterine Growth In Term Newborns

Including gene, maternity body weight and nutritional status, the intrauterine fetal growth ofterm newborns is influenced by a variety of hormone and cell factors such as insulin and resisitin.The objectives of this paper is to study the concentration of serum resistin and insulin in differentforms of term newborns, and analyze the relationship with intrauterine fetal growth, and explorethe possible functions and mechanism they are in fetal growth and development.Object and Method1. Object: The clinical data of 41 studied term infants were collected randomly frombabies dwell on the department of neonatus in ShanXi children’s hospital from 2010-10-01 to 2011-05-31. 14 small for gestational age (SGA), 13 appropriate for gestational age(AGA), and 14 large for gestational age (LGA). Selected standard: full-term infants; eutocia; without choking history andserious illness performance, only swallow syndrome andmild inhaled syndrome; admission age<24h, Except children whose mother with gestation period hypertention, endocrine disease, severe anaemia, malnutrition, infection, uterine abnormalities, uterine fibroids, abnormally of umbilical cord and placenta.2. Method: Get femoral vein blood 2 ml to put in a tube promoting coagulation when the infants addmited to hospital. Centrifugate 1000r/10min, put the supernatant fluid into refrigerator under -20℃. Mensurate Resistin and Insulin with ELISA.3. Statitic method: Treat the date with SPSS 13.0 statistic software, represent date with Mean±SD. Analyze the differences between Resistin level, Insulin level and birth weight with univariate ANOVA. Use pearsonn linear correlation to identify the relationship among them. P＜0.05 was considered statistically significant.Results1. Serum Resistin levels decreased in larger birth weight (BW) full-term infant as comparedwith that of smaller BW ones, that of SGA group was higher than that of LGA group (P<0.05);2. Serum Insulin levels increased in larger birth weight (BW) full-term infant as comparedwith that of smaller BW ones, that of LGA group was higher than that of AGA group (P<0.05)，and that of SGA group was lower than that of AGA group (P<0.05);3. Serum Resistin levels and neonatal birth weight was significantly negatively correlated (r=-0.435, P <0.05); 4. Serum insulin levels and neonatal birth weight was significantly positively correlated（r=0.695, P <0.01);5. Serum Resistin levels was not significantly associated with serum Insulin levels (r=-0.293, P >0.05).ConclutionSerum Resistin levels decreased in larger BW full-term infant as compared with that ofsmaller BW ones, and had negative correlation with BW. It is suggested that Resistin involved inthe regulation of fetal growth and development, and may played a negative role in fetal weightgrowth. But the exact correlations between resistin and insulin in regulating intrauterine growthhave not yet definitely studied.