Retrospective Study:Effect Of Using Proton Pumpinhibitor On Clinical Outcomes In The Patients After PCI

Objctive:this study was to evaluate whether effect of using proton pump inhibitor (PPI) on clinical outcomes in Chinese population after PCI.Methods:1504 patients with PCI, the screening was divided into the use of PPI 298 patients of group A,no with PPI 1206 patients of group B.All of the patients with clopidogrel 300 mg or 600 mg before PCI, with clopidogrel 75 mg and aspirin 100 mg daily after PCI,compared to the rate of major adverse clinical events among two groups in one year.Results:compared to the rate of major adverse clinical events of group A and group B (combined end point 3.85% vs 4.39%, All cause of death 0.35% vs1.97%, myocardial infarction 0.70% vs 0.98%, reascularization 1.05% vs 2.51%, heart failure3.50% vs 3.67%),there were no significant difference between two groups with All cause of death, myocardial infarction, reascularization, heart failure(P>0.05). angina 15.03% vs 10.12%,there were significant difference between two groups(P<0.05),A group higther than B group, there were no significant difference between two groups with cumulative survival(Log-rank test P>0.05).Conclusions:Using proton pump inhibitors can increase the rate of angina after PCI, but don’t increase the rate of combined end point, All cause of death, myocardial infarction, reascularization, heart failure Cardiovascular adverse events.