Clinical Significance Of Serum Vascular Endothelial Growth Factor And Interleukin-17 In Multiple Myeloma

Objective To investigate the clinical significance of the change of vascular endothelial growth factor (VEGF) and interleukin-17(IL-17) level in multiple myeloma (MM).Methods 40 newly diagnosed MM patients, including 9 In StageⅠ,18 In StageⅡ,13 In StageⅢ.25 patients were treated with VAD regimen, and 15 patients were treated with the combination of PD.20 healthy controls were enrolled in this study. The serum VEGF and IL-17 level were determined by ELISA.Results Serum VEGF and IL-17 concentrations in patients with MM were significantly higher than those of the healthy controls (P<0.01),There was significant difference in VEGF and IL-17 levels in various clinical stages of MM. VEGF levels In StageⅢwere significantly higher than In StageⅡ(P< 0.05) and IL-17 level In StageⅡwere significantly higher than In StageⅠ(P<0.05). Serum VEGF and IL-17 concentrations were significantly decreased in MM patients after treatment than those without treatment (P<0.05), and the serum VEGF and IL-17 concentrations were significantly decreased in MM patients who were treated with VAD regimen than those treated with PD regimen.Conclusion VEGF and IL-17 are correlated with angiogenesis and prognosis in MM, Serum VEGF and IL-17 levels are helpful to diagnose the clinical stages, and severity of MM.