Expression And Clinical Significance Of Somatostatin Receptor Subtype SSTR2,3in Lymphoma

Objectives To investigate the expression of somatostatin receptor subtypes SSTR2and SSTR3in different types, different parts of lymphoma..Methods The expressions of SSTR2and SSTR3gene in105cases lymphoma paraffin-embedded specimens were detected by RT-PCR.Results The positive expression rate of SSTR2and SSTR3in the mucosa-associated lymphoma was (8/27),(6/27), diffuse large B-cell lymphoma (14/36),(12/36), NK/T cells lymphoma (9/22),(6/22), and Burkitt’s lymphoma (6/20),(7/20). The total positive expression rate of SSTR2was35.24%(37/105), and SSTR329.52%(31/105). In which the lesions in the diaphragm the total positive expression rate of SSTR2and SSTR3were44.44%(24/54),37.04%(20/54),both of a statistical difference (x2=4.13, p=0.04). The subdiaphragmatic total positive rate respectively25.49%(13/51),21.57%(11/51), no statistical difference(χ2=3.02, p=0.08).Conclusion We found that partial lymphoma at least express one kind of somatostatin receptors of SSTR2.SSTR3, but the expression rate was low.However lymphomas are highly radiosensitive tumors whether low expression of somatostatin receptors in lymphoma is sufficient for diagnosis and targeting treatment in these tumors needs further study.