Vacant Weaving Method And Mechanical Analysis Of Polyethylene Terephthalate Fiber For Artificial Ligament

BACKGROUND: With the development and growth of national strength andimprovement of living standards, the sport is gaining popularity, and ligamentinjury incidence increased year by year, a conservative estimate of the annualligament injury cases should be no less than10million. Different from bonetissue, ligaments once broken can not be natural repair and healing, and causesecondary damage such as joint instability or other structures, eventually leadingto joint with severe dysfunction. There are many ligament reconstruction methodsinvented, and autologous or allogeneic tendon graft reconstruction gets a broadconsensus, but it is almost inevitable for complications that autologous tendon(patellar tendon/hamstring muscle) will cause the weakness of the donor site,patellar tendinitis and patellar fat pad contracture; allogeneic tendon will causeimmune rejection, growth delay and the increasing risk of spread of infectious diseases. In recent years, artificial ligament graft reconstruction of joint functiongets a chief concern, it has become a routine surgical reconstruction of jointfunction in a foreign country, however, there is no domestic artificial ligamentsproducts with independent intellectual property; the existing products of theforeign country show a poor biocompatibility, long-term repair effect is less thanideal, still amounts to less than perfect results. PET (polyethylene terephthalate,)as a representative of the polyester, is fully able to meet the natural ligament ofthe human body mechanics requirements, we intend to use woven PET fiber tobuild ligament scaffolds, and analyze the mechanical properties of the scaffolds,finally we want to explore the feasible artificial anterior cruciate ligamentscaffolds by the materials.1. Vacant weaving of Polyethylene terephthalate scaffoldsOBJECTIVE: By PET (polyethylene terephthalate,) material weaving,build the tissue engineering ligament scaffolds. METHOD: Using RSJ4multi-comb lace and warp knitting machines, different strength PET singlefibers are woven through the warp, observe its internal structure by electronmicroscopy. RESULTS: The scaffolds built by woven PET has structuralstability, and it is suitable for constructing artificial ligament. CONCLUSIONS:The structural design of the scaffolds is reasonable and consistent with thedesign requirements of the artificial ligament scaffolds.2. Mechanical Properties of artificial ligament scaffoldsOBJECTIVE: Through the analysis of PET (polyethylene terephthalate)mechanical performance, Explore the feasibility of using the materials to construct tissue engineered ligament scaffolds. METHOD: test and analysismechanical properties of the woven scaffold material and disinfected scaffoldsby using electronic tensile testing machine (H25KS-S, Hounsfield TestEquipment Ltd, UK). RESULTS: The ultimate tensile strength and othermechanical indicators have reached the mechanical requirements of the anteriorcruciate ligament. And irradiation sterilization has no short-term effects of onthe mechanical properties of scaffolds. CONCLUSIONS: The scaffold materialhas excellent mechanical properties, disinfection has no short-term impact onthe mechanical properties. It is expected to be an ideal tissue engineeringscaffolds of anterior cruciate ligament after improving its biological properties.