The Analysis Of Clinical Features Of Alcoholic Cirrhosis

Objective：To analyze the clinical features of alcoholic cirrhosis(AC).Methods: A retrospective study was conducted in a consecutive cohort of97alcoholiccirrhosis patients drinking histories admitted in Fujian Provincial hospital fromJanuary2006to December2011, compared with decompensation of compensatoryperiod of alcohol consumption and drinking time; And126patients with hepatitis bcirrhosis (HBC) diagnosed over the same period were served as control group,thedetailed clinical data of both groups including age, sex, hospital stay, familyhistory,past history,laboratory test, drug therapy, concomitant disease,complicationsas well as curative effect were recorded. The two groups of clinical data ofcomparative research, and analysis of2006to2011alcoholic cirrhosis of the trend.Results: The percentage of alcoholic cirrhosis was about7.26％to12.6％,andincreasing annually.The quantity and time of intaking alcohol in decompensation washigher and longer than those of compensation(the quantity of intaking alcohol100.4±12.9vs168.7±38.6；The time of intaking alcohol23.4±2.24vs35.1±7.52).The value of serum total bilirubin (TBIL), aspartate aminotransferase(AST),aspartateaminotransferase/alanineaminotransferase(AST/ALT),gammaglutamyl transpeptidase(GGT) and mean corpuscular volume(MCV) of AC group was strikingly higher thanthose of HBC group (all P<0.05), and TBIL,AST/ALT, MCV could reflect theseverity of AC，the higher of TBIL,AST/ALT and MCV, the more advanced disease.Patients with AC had a significantly increased prevalence of peptic ulcer、cholelithiasis and acute pancreatitis compared with those with HBC（peptic ulcer:13.4%vs4.8%；cholelithiasis:26.8%vs13.5%；acute pancreatitis:6.2%vs0.8%）；The percentage of complications in AC group, including upper gastrointestinalhemorrhage (UGH), biliary tract infection and hepatic encephalopathy(HE), weresignificantly higher than those of HBC group（upper gastrointestinal hemorrhage: 31.9%vs17.5%；biliary tract infection:14.4%vs6.4%；hepatic encephalopathy:10.3%vs3.2%）, whereas hepatocellular carcinoma in alcoholic cirrhosis group wassignificantly lower than those in hepatitis b cirrhosis group（15.5%vs32.5%），theyhad difference. The curative effect and mortality of patients with alcoholic cirrhosiswere obviously better than hepatitis b cirrhosis in the same period.Conclusion: Alcoholic cirrhosis accounted for a percentage of the total number ofcirrhosis was increasing annually in the trend. Compared with hepatitis b cirrhosispatients, GGT, MCV, TBIL, AST and the ratio of AST/ALT increased significantlyin alcoholic cirrhosis patients．TBIL,AST/ALT,MCV value could reflect the severityof alcoholic cirrhosis. Patients with alcoholic cirrhosis had higher comorbidity ofpeptic ulcers, cholelithiasis, acute pancreatitis, and had higher complication of uppergastrointestinal hemorrhage, biliary tract infection and hepatic encephalopathy.Thecurative effect and prognosis of alcoholic cirrhosis patients were relatively better thanhepatitis b cirrhosis patients after abstinence.