Analysis Of85Cases Of Endoscopic Obvious Mucosa Injury Nonsteroidal Anti-inflammatory Drug Gastropathy

Objective:To investigate the clinical characteristics and risk factors of gastroduodenal damages induced by nonsteroidal anti-inflammatory drugs (NSAIDs). Strengthen to understand the disease.Methods:The sample consisted of85patients whose gastroduodenal damages were induced by nonsteroidal anti-inflammatory drugs (NSAIDs) at the first affiliated hospital of Fujian medical university from the January2010to April2012. According to the endoscopic diagnosis, the patients were divided into two groups, erosive gastritis group and ulcer group. Record the patients’ age, sex, clinical symptoms, previous ulcer history, H.pylori infection, smoking history and kinds of NSAIDs.Results:①Of85patients of gastroduodenal damages induced by NSAIDs,male49,female36, the male and female ratio1.36:1,mean age (61.8±13.17) years, age range from16-80years,There were47patients who were more than60years old,38patients who were less than60years old, the degree of gastroduodenal damages in patients who were more than60years old was more serious than the patients who were less than60years old (P<0.05).②Erosive gastritis in52(61.2%), located mainly in the gastric antrum (84.6%); Peptic ulcer in33(38.8%), mainly to active period of24patients (72.7%),also located mainly in the gastric antrum (60.6%), The HP infection in erosive gastritis group12cases (23.1%), The HP infection in ulcer group Hp21cases (66.9%), The Hp infection rates in ulcer group were higher than the erosive gastritis group.(P<0.05).③There were no differences in the clinical symptoms between Erosive gastritis group and ulcer group, abdominal pain as the main symptom.④Use single NSAIDs drug in52cases, two NSAIDs or combined with application of hormone, anticoagulants in33cases. The degree of gastroduodenal damages in patients who used two NSAIDs was more serious than the patients who used single NSAID drug (P<0.05);Drug use time7to15days its relevance stomach highest incidence, medication for15d-1m person, erosive gastritis is a high incidence of peptic ulcer (P<0.05); Time>6m taking the peptic ulcer more erosive gastritis high rate (P<0.05).⑤Erosive gastritis group always have the interviewer ulcer in3, peptic ulcer group he had a history of ulcer7cases, whereas patients with a prior the more easily again hair ulcer (P<0.05).Conclusions:The degree of gastroduodenal damages in patients who were more than60years old was more serious than the patients who were less than60years old. It occur basically in gastric antrum. The Hp infection rates in ulcer group were higher than the erosive gastritis group. The mean clinical symptoms was abdominal pain. The degree of gastroduodenal damages in patients who used two NSAIDs was more serious than the patients who used single NSAIDs drug, drug use time7～15d highest incidence; Previous ulcer NSAIDs correlation history is the risk factors of stomach problems.