Effect Of Benazepril And Valsartan On Paraquat-induced Lung Injury

Objectives: The thesis is to study the therapeutic effect of Angiotensin-ConvertingEnzyme Inhibitors Benazepril and antiotensinII receptor antagonists valsartan againstparaquat-induced lung injury.Methods:Fourty acute paraquat poisioning patients between Mar2005and Mar2010in ourhospital were divided into A group(treated with Angiotensin-Converting EnzymeInhibitors Benazepril and antiotensinII receptor antagonists valsartan，n=22) and Bgroup (treated with conventional therapy，n=18). Benazepril was used in A group onthe basis of conventional therapy,with a dose of20mg～60mg/d Valsartan was usedin A groupwith a dose of160mg～320mg/d. Thearterial partial pressure ofoxygen(PaO2)、the survival time of dead cases and the prognosis were observed.Results:1.The age、gender、amount of paraquat taken、time of being in hospitalbetween A and B groups before treated were not significant(P>0.05).2.Register the day1st and day7th PaO2between A and B group, it was not significantat the time patients being in hospital(P＞0.05). The respective PaO2of A group were(88.9±13.3)mmHg and(82.8±16.2)mmHg, and the PaO2of A group after treatedwassignificantly higher compared to B group(P＜0.05). Meanwhile, therespectivesurvival time of dead cases were (19.5±4.3)days and (15.3±2.5)days, A group wasmuch longer than B group(P＜0.01).3.Themortalities of two groups were40.9%and55.6%, it was not significantbetweentwo groups(P>0.05).Conclusions: Angiotensin-Converting Enzyme Inhibitors Benazepril andAntiotensinⅡ receptor antagonists valsartan can reduce the course of lung fibrosis of patients who suffered from acute paraquat poisioning, prolong the survival time ofdead cases, but it cannot reduce the death rate.