Effect Of Antiotensin II Receptor Antagonists Valsartan On Paraquat-induced Lung Injury

Objectives: The thesis is to study the therapeutic effect of antiotensinII receptor antagonists valsartan against paraquat-induced lung injury.Methods:Twenty acute paraquat poisioning patients between Mar 2002 and Mar 2010 in our hospital were divided into A group(treated with antiotensinII receptor antagonists valsartan,n=8) and B group (treated with conventional therapy,n=12). Valsartan was used in A group on the basis of conventional therapy,with a dose of 160mg～320mg/d. The arterial partial pressure of oxygen(PaO2),the survival time of dead cases and the prognosis were observed.Results: 1.The age,gender,amount of paraquat taken,time of being in hospital between A and B groups before treated were not significant(P>0.05). 2.Register the day1st and day7th PaO2 between A and B group, it was not significant at the time patients being in hospital(P >0.05). The respective PaO2 of A group were (60.3±2.8)mmHg and (51.2±3.2)mmHg, and the PaO2 of A group after treated was significantly higher compared to B group(P<0.05). Meanwhile, the respective survival time of dead cases were (19.5±4.3)days and (15.3±2.5)days, A group was much longer than B group(P<0.01).3.The mortalities of two groups were 58.3% and 50%, it was not significant between two groups(P>0.05).Conclusions: AntiotensinII receptor antagonists valsartan can reduce the course of lung fibrosis of patients who suffered from acute paraquat poisioning, prolong the survival time of dead cases, but it cannot reduce the death rate.