| ObjectiveTo investigate the relationship between the prolonged QTc interval and themulti-cardiovascular risk factors in the patients with type2diabetesmellitus(T2DM).MethodsMedical data of3426patients with T2DM from2003to2010based on thedatabase of diabetic complications assessment were analyzed after excludingpatients who had coronary heart diseases, arrhythmia, myocardial infarction, which may cause abnormal QTc. These data included the duration of diabetes,height, weight, waist circumference, blood pressure, blood glucose, HbA1c,lipids, creatinine, urinary protein excretion, ECG, Ankle-brachial index,retinopathy and peripheral neuropathy, ect.Results1.The patients were divided into normal QTc interval group (group A, QTc≤0.44s, n=2157) and prolonged QTc interval group (group B, QTc>0.44s, n=1269). The multi-cardiovascular risk factors were compared between the twogroups and further analyzed. Compared with group A, the patients in group Bwere older[(55.6±11.0) vs (54.6±10.9) years], had longer diabetes duration[36(12,96) vs36(6,84)months, median(P25, P75)], more females (51.5%vs41.5%), shorter body height[(1.64±0.08) vs (1.65±0.08) m], bigger body massindex(BMI)[(26.2±3.6) vs (25.8±3.2) kg/m2], bigger waist circumference[(89.7±9.6) vs (88.2±9.5) cm], bigger hip circumference [(95.4±7.3) vs(94.4±6.6)cm], higher waist hip ratio(WHR)[(0.94±0.07) vs (0.93±0.08)],higher blood pressure [(134.8±20.3)/(76.9±10.2) vs (130.1±19.1)/(74.5±9.6)mmHg], higher heart rate[(82.9±10.2) vs (70.7±10.1)beats/min], higherHbA1c [(8.0±2.0)%vs (7.7±1.9)%], higher post-meal glucose[(13.7±5.1) vs(12.8±4.8) mmol/L], higher fasting insulin[(9.4±8.6) vs (8.2±7.5)IU/ml],higher total cholesterol [(5.1±1.1) vs (5.0±1.1)mmol/L], higher triglyceride[(2.4±2.6) vs (2.2±2.5)mmol/L], and higher urine albumin/creatinine (Alb/Cr)[15(8,36) vs12(7,27) mg/g, median(P25, P75)]. All these indices weresignificantly different between the two groups(P＜0.05). Logistic regressionanalysis showed that age, sex, BMI, waist circumference, WHR, heart rateand Cr were significantly associated with prolonged QTc interval.2.The prevalence of prolonged QTc interval was32.9%in the group with age＜40yrs，36.2%with age40–60yrs and39.7%with age＞60yrs（P<0.05）. The prevalence of prolonged QTc interval was35.5%in the groupwith duration of diabetes0-60months,39.3%with61-120months,39.1%with121-180months and44.8%with over180months（P<0.05）. Theprevalence of prolonged QTc interval was1.7%in the group with heart rate＜60,38.4%in the group with60-100,88.5%in the group with＞100beat/minute（P<0.01）.Compared with the control group, the prevalence ofprolonged QTc interval was higher in hypertension group [44.1%vs33.7%(P<0.01)], in postural hypotension group [40.0%vs35.9%(P<0.05)] and inhyperlipidemia group [39.4%vs32.1%(P<0.01)].3.QTc was0.434±0.03s in the group with ABI≤0.6,0.429±0.03s in thegroup with0.61-0.9,0.425±0.03s in the0.91-1.3,0.419±0.03s with>1.3,respectively. But the significant differences of the QTc were found onlybetween Group4and group1/2/3.ConclusionsMore than one third of T2DM patients present with prolonged QTcinterval and more severe multi-cardiovascular risk factors，The patients withlonger QTc have more severe multi-cardiovascular risks, also associated withperipheral artery disease. |
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