The Clinical Significance Of Serum25(OH) D Changes In Different Glucose Metabolic State

Objective: Explore the relationship between serum25(OH) D level with type2diabetes.Method: Choose healthy check-up in the same period30patients (NGT) for group1,patients with abnormal glucose tolerance (IGT/IFG)32cases of group2, newlydiagnosed type2diabetes mellitus (T2DM) patients48cases for group3, thetreatment of type2diabetic patients with50cases of group4, record the basicinformation and clinical observation clinical index. Analysis of the fourgroups-serum25(OH) D3level and age, gender, BMI, SBP and DBP, FPG, TG,CHOL,2hPG, FINS, HbA1c and islet function relations.Results:1. Between each group the BMI, TG, DBP,25(OH) D, FPG,2hPG, FINS,homa-ir, HOMA-β, HbA1c are statistically significant differences, P <0.05. Serum25(OH) D levels significantly reduce in sugar metabolism disorders，the differencebetween each group was not statistically significant.2. Related analysis showed that the serum25(OH) D level and age, BMI,FPG, P2hPG, HbA1c into negative correlation (r=-0.396,-0.229,0.248,0.184,0.213, P <0.05), and HOMA-β a positive correlation (r=0.176, P <0.05), and TG,CHOL, SBP and DBP, homa-ir, FINS have no obvious related (P>0.05).3. Multiple stepwise regression analysis showed that age, BMI, sex, HbA1cinfluence is serum25(OH) D level-the main factors (t=4.271,-3.829,4.094,2.964,P <0.05).Conclusion:1. Serum25(OH) D level is closely related to sugar metabolismcondition，the lack of vitamin D may cause abnormal glucose tolerance and the riseof blood sugar levels. Long-term poor blood sugar control in the metabolicabnormalities may result in serum25(OH) D reduced.2. Age, BMI, sex, HbA1c is the main influence factors of serum25(OH) D level.