Studies On Preparation Technique And Quality Tandard Of Ivermectin Levamisole Transdermal Solution

Ivermectin is a new, broad-spectrum, high efficiency, low toxicitydrug. For the control of parasitic diseases in vivo,Wide range ofapplications.Now widely used in animals, nematodes, mites, ticks andother parasitic diseases in vivo.Broad-spectrum anthelmintic， Lowtoxicity for roundworm, hookworm, pinworm, heartworm and otherdiseases,Effective for most gastrointestinal nematodes,Combined withivermectin and levamisole, a wider range of insect can be made goodeconomic.Macrolide drive internal and external parasites with imidazoleand thiazole drugs combined with medicines, can increase the range ofbroad-spectrum anthelmintics, efficacy overlay, significantly increasedthe effect of drugs.In this thesis, ivermectin, levamisole transdermal solution’spreparation and its quality standards have been studied, and gavestability test. Optimized in terms of preparation of ivermectin,levamisole prescription transdermal technology solution。 Qualitystandards in research, through research, developed ivermectin,levamisole draft quality standards for transdermal solution, and thestability study。Paper is divided into four parts:The first part is the introduction and literature review, Ivermectinsolution described transdermal Research status, accuracy of project,Prescription based, Stability and effectiveness of case.The second part is ivermectin, levamisole solution transdermalformulation design, process of selection and preparation. Including basicsolvent Formulation Screening. Study the interaction of the main drugsand excipients. Finalized to ivermectin, levamisole-based drug, N Zhuoketone laurel oil, the new long-chain triglycerides, soybean oil as aprescription materials.The third part is the quality of research and development of qualitystandards. Quality of preparation of this part of the study and developthe quality standards of the draft. We are ivermectin and levamisoledeveloped a method of identifying; One method for the identification oflevamisole is TLC. It is a method of innovation, Which in the past aboutthe quality standards of levamisole is not used. Determination of areasin the two main drugs were developed method for the determination, We useHPLC test ivermectin, This method can accurately analyze the sample contents of ivermectin; We examined the effects of levamisole using theclassical Non-aqueous titration. This method requires simple testingequipment, easy to operate, wide range of applications, available forgeneral laboratory.The fourth part is ivermectin, levamisole transdermal solutionstability test. We investigated separately the accelerated stability andlong-term stability of it. Accelerated test conditions are Temperature(40℃±2℃), relative humidity(20%±2%).We focus on examination of theproduct character, identification, ivermectin composition, content.Long-term test is carried out under the conditions close to the actualstorage conditions of drug. Our Purpose is to provide the basis for thevalidity of drug. the project are the same with acceleration test. Theresults showed that: ivermectin, levamisole transdermal solution is nochange in the conditions and time required to stabilize.